3HF9

Crystal Structure of Mycobacterium Tuberculosis Proteasome open-gate mutant modified by inhibitor GL1

Summary for 3HF9

Entry DOI	10.2210/pdb3hf9/pdb
Related	3HFA
Descriptor	Proteasome (Alpha subunit) PrcA, Proteasome (Beta subunit) PrcB (3 entities in total)
Functional Keywords	binding sites, oxazolidin-2-one, mycobacterium tuberculosis, protease inhibitors, proteasome endopeptidase complex, protein subunits, substrate specificity, open gate, mutant, hydrolase, proteasome
Biological source	Mycobacterium tuberculosis More
Total number of polymer chains	56
Total formula weight	1435622.52
Authors	Li, D.,Li, H. (deposition date: 2009-05-11, release date: 2009-09-15, Last modification date: 2023-11-22)
Primary citation	Lin, G.,Li, D.,de Carvalho, L.P.,Deng, H.,Tao, H.,Vogt, G.,Wu, K.,Schneider, J.,Chidawanyika, T.,Warren, J.D.,Li, H.,Nathan, C. Inhibitors selective for mycobacterial versus human proteasomes. Nature, 461:621-626, 2009 Cited by PubMed: 19759536 DOI: 10.1038/nature08357 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.878 Å)

Structure validation