4V6B
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8A9L
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![BU of 8a9l by Molmil](/molmil-images/mine/8a9l) | Cryo-EM structure of alpha-synuclein filaments from Parkinson's disease and dementia with Lewy bodies | 分子名称: | Alpha-synuclein, Unknown fragment | 著者 | Yang, Y, Shi, Y, Schweighauser, M, Zhang, X.J, Kotecha, A, Murzin, A.G, Garringer, H.J, Cullinane, P, Saito, Y, Foroud, T, Warner, T.T, Hasegawa, K, Vidal, R, Murayama, S, Revesz, T, Ghetti, B, Hasegawa, M, Lashley, T, Scheres, H.W.S, Goedert, M. | 登録日 | 2022-06-28 | 公開日 | 2022-08-31 | 最終更新日 | 2022-11-09 | 実験手法 | ELECTRON MICROSCOPY (2.16 Å) | 主引用文献 | Structures of alpha-synuclein filaments from human brains with Lewy pathology. Nature, 610, 2022
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6NWP
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![BU of 6nwp by Molmil](/molmil-images/mine/6nwp) | Chronic traumatic encephalopathy Type I Tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Falcon, B, Zivanov, J, Zhang, W, Murzin, A.G, Garringer, H.J, Vidal, R, Crowther, R.A, Newell, K.L, Ghetti, B, Goedert, M, Scheres, H.W. | 登録日 | 2019-02-07 | 公開日 | 2019-03-27 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature, 568, 2019
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6NWQ
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![BU of 6nwq by Molmil](/molmil-images/mine/6nwq) | Chronic traumatic encephalopathy Type II Tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Falcon, B, Zivanov, J, Zhang, W, Murzin, A.G, Garringer, H.J, Vidal, R, Crowther, R.A, Newell, K.L, Ghetti, B, Goedert, M, Scheres, H.W. | 登録日 | 2019-02-07 | 公開日 | 2019-03-27 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature, 568, 2019
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8P34
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![BU of 8p34 by Molmil](/molmil-images/mine/8p34) | Tau filaments extracted from human brain with the DeltaK281 mutation in MAPT | 分子名称: | Microtubule-associated protein tau | 著者 | Schweighauser, M, Garringer, H.J, Klingstedt, T, Masuda-Suzukake, M, Murrell, J.R, Vidal, R, Scheres, S.H.W, Goedert, M, Ghetti, B, Newell, K.L. | 登録日 | 2023-05-17 | 公開日 | 2023-07-05 | 最終更新日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | 主引用文献 | Mutation ∆K281 in MAPT causes Pick's disease. Acta Neuropathol, 146, 2023
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6HRE
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![BU of 6hre by Molmil](/molmil-images/mine/6hre) | Paired helical filament from sporadic Alzheimer's disease brain | 分子名称: | Microtubule-associated protein tau | 著者 | Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M. | 登録日 | 2018-09-26 | 公開日 | 2018-10-10 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold. Acta Neuropathol., 136, 2018
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6HRF
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![BU of 6hrf by Molmil](/molmil-images/mine/6hrf) | Straight filament from sporadic Alzheimer's disease brain | 分子名称: | Microtubule-associated protein tau | 著者 | Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M. | 登録日 | 2018-09-26 | 公開日 | 2018-10-10 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold. Acta Neuropathol., 136, 2018
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6GX5
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![BU of 6gx5 by Molmil](/molmil-images/mine/6gx5) | Narrow Pick Filament from Pick's disease brain | 分子名称: | Microtubule-associated protein tau | 著者 | Falcon, B, Zhang, W, Murzin, A.G, Murshudov, G, Garringer, H.J, Vidal, R, Crowther, R.A, Ghetti, B, Scheres, S.H.W, Goedert, M. | 登録日 | 2018-06-26 | 公開日 | 2018-09-12 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of filaments from Pick's disease reveal a novel tau protein fold. Nature, 561, 2018
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7NRV
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![BU of 7nrv by Molmil](/molmil-images/mine/7nrv) | Paired helical filament from Alzheimer's disease with PET ligand APN-1607 | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2021-03-04 | 公開日 | 2021-03-24 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta Neuropathol, 141, 2021
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7NRQ
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![BU of 7nrq by Molmil](/molmil-images/mine/7nrq) | Paired helical filament from primary age-related tauopathy brain | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2021-03-04 | 公開日 | 2021-03-24 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta Neuropathol, 141, 2021
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7NRS
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![BU of 7nrs by Molmil](/molmil-images/mine/7nrs) | Conformation 1 of straight filament from primary age-related tauopathy brain | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2021-03-04 | 公開日 | 2021-03-24 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | 主引用文献 | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta Neuropathol, 141, 2021
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7NRT
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![BU of 7nrt by Molmil](/molmil-images/mine/7nrt) | Conformation 2 of straight filament from primary age-related tauopathy brain | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2021-03-04 | 公開日 | 2021-03-24 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | 主引用文献 | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta Neuropathol, 141, 2021
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7NRX
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![BU of 7nrx by Molmil](/molmil-images/mine/7nrx) | Straight filament from Alzheimer's disease with PET ligand APN-1607 | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Murzin, A.G, Falcon, B, Epstein, A, Machin, J, Tempest, P, Newell, K.L, Vidal, R, Garringer, H.J, Sahara, N, Higuchi, M, Ghetti, B, Jang, M, Scheres, S.H.W, Goedert, M. | 登録日 | 2021-03-04 | 公開日 | 2021-03-24 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | 主引用文献 | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta Neuropathol, 141, 2021
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7P68
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![BU of 7p68 by Molmil](/molmil-images/mine/7p68) | Globular glial tauopathy type 3 tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2021-10-27 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7P6D
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![BU of 7p6d by Molmil](/molmil-images/mine/7p6d) | Argyrophilic grain disease type 1 tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2021-10-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7P67
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![BU of 7p67 by Molmil](/molmil-images/mine/7p67) | Globular glial tauopathy type 2 tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2021-10-27 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7P6E
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![BU of 7p6e by Molmil](/molmil-images/mine/7p6e) | Argyrophilic grain disease type 2 tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2021-10-27 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7P6A
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![BU of 7p6a by Molmil](/molmil-images/mine/7p6a) | Limbic-predominant neuronal inclusion body 4R tauopathy type 1a tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2021-10-27 | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7P65
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![BU of 7p65 by Molmil](/molmil-images/mine/7p65) | Progressive supranuclear palsy tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2021-10-27 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7P66
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![BU of 7p66 by Molmil](/molmil-images/mine/7p66) | Globular glial tauopathy type 1 tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2021-10-27 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7P6B
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![BU of 7p6b by Molmil](/molmil-images/mine/7p6b) | Limbic-predominant neuronal inclusion body 4R tauopathy type 1b tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2021-10-27 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7P6C
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![BU of 7p6c by Molmil](/molmil-images/mine/7p6c) | Limbic-predominant neuronal inclusion body 4R tauopathy type 2 tau filament | 分子名称: | Microtubule-associated protein tau | 著者 | Shi, Y, Zhang, W, Yang, Y, Murzin, A.G, Falcon, B, Kotecha, A, van Beers, M, Tarutani, A, Kametani, F, Garringer, H.J, Vidal, R, Hallinan, G.I, Lashley, T, Saito, Y, Murayama, S, Yoshida, M, Tanaka, H, Kakita, A, Ikeuchi, T, Robinson, A.C, Mann, D.M.A, Kovacs, G.G, Revesz, T, Ghetti, B, Hasegawa, M, Goedert, M, Scheres, S.H.W. | 登録日 | 2021-07-15 | 公開日 | 2021-09-15 | 最終更新日 | 2021-10-27 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structure-based classification of tauopathies. Nature, 598, 2021
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7Q4M
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![BU of 7q4m by Molmil](/molmil-images/mine/7q4m) | Type II beta-amyloid 42 Filaments from Human Brain | 分子名称: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | 著者 | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | 登録日 | 2021-11-01 | 公開日 | 2021-11-24 | 最終更新日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-EM structures of amyloid-beta 42 filaments from human brains. Science, 375, 2022
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7Q4B
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![BU of 7q4b by Molmil](/molmil-images/mine/7q4b) | Type I beta-amyloid 42 Filaments from Human Brain | 分子名称: | Amyloid-beta precursor protein, UNKNOWN ATOM OR ION | 著者 | Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M. | 登録日 | 2021-10-30 | 公開日 | 2021-11-24 | 最終更新日 | 2023-03-08 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Cryo-EM structures of amyloid-beta 42 filaments from human brains. Science, 375, 2022
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8CE7
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![BU of 8ce7 by Molmil](/molmil-images/mine/8ce7) | Type1 alpha-synuclein filament assembled in vitro by wild-type and mutant (7 residues insertion) protein | 分子名称: | Alpha-synuclein | 著者 | Yang, Y, Garringer, J.H, Shi, Y, Lovestam, S, Peak-Chew, S.Y, Zhang, X.J, Kotecha, A, Bacioglu, M, Koto, A, Takao, M, Spillantini, G.M, Ghetti, B, Vidal, R, Murzin, G.A, Scheres, H.W.S, Goedert, M. | 登録日 | 2023-02-01 | 公開日 | 2023-03-01 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | New SNCA mutation and structures of alpha-synuclein filaments from juvenile-onset synucleinopathy. Acta Neuropathol, 145, 2023
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