6NWP

Chronic traumatic encephalopathy Type I Tau filament

Summary for 6NWP

Entry DOI	10.2210/pdb6nwp/pdb
EMDB information	0527
Descriptor	Microtubule-associated protein tau (2 entities in total)
Functional Keywords	tau, chronic traumatic encephalopathy, filament, amyloid, protein fibril
Biological source	Homo sapiens (Human)
Total number of polymer chains	6
Total formula weight	275519.23
Authors	Falcon, B.,Zivanov, J.,Zhang, W.,Murzin, A.G.,Garringer, H.J.,Vidal, R.,Crowther, R.A.,Newell, K.L.,Ghetti, B.,Goedert, M.,Scheres, H.W. (deposition date: 2019-02-07, release date: 2019-03-27, Last modification date: 2022-03-30)
Primary citation	Falcon, B.,Zivanov, J.,Zhang, W.,Murzin, A.G.,Garringer, H.J.,Vidal, R.,Crowther, R.A.,Newell, K.L.,Ghetti, B.,Goedert, M.,Scheres, S.H.W. Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature, 568:420-423, 2019 Cited by PubMed: 30894745 DOI: 10.1038/s41586-019-1026-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.3 Å)

Structure validation