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1CJE
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BU of 1cje by Molmil
ADRENODOXIN FROM BOVINE
分子名称: ADRENODOXIN, FE2/S2 (INORGANIC) CLUSTER
著者Pikuleva, I.A, Tesh, K, Waterman, M.R, Kim, Y.
登録日1999-04-12
公開日2000-01-21
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The tertiary structure of full-length bovine adrenodoxin suggests functional dimers.
Arch.Biochem.Biophys., 373, 2000
2Q9G
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BU of 2q9g by Molmil
Crystal structure of human cytochrome P450 46A1
分子名称: Cytochrome P450 46A1, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE
著者White, M.A, Mast, N.V, Johnson, E.F, Stout, C.D, Pikuleva, I.A.
登録日2007-06-12
公開日2008-06-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2Q9F
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BU of 2q9f by Molmil
Crystal structure of human cytochrome P450 46A1 in complex with cholesterol-3-sulphate
分子名称: CHOLEST-5-EN-3-YL HYDROGEN SULFATE, Cytochrome P450 46A1, GLYCEROL, ...
著者White, M.A, Mast, N.V, Johnson, E.F, Stout, C.D, Pikuleva, I.A.
登録日2007-06-12
公開日2008-06-17
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2XKR
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BU of 2xkr by Molmil
Crystal Structure of Mycobacterium tuberculosis CYP142: A novel cholesterol oxidase
分子名称: PROTOPORPHYRIN IX CONTAINING FE, PUTATIVE CYTOCHROME P450 142, TETRAETHYLENE GLYCOL
著者Driscoll, M, McLean, K.J, Levy, C.W, Lafite, P, Mast, N, Pikuleva, I.A, Rigby, S.E.J, Leys, D, Munro, A.W.
登録日2010-07-12
公開日2010-09-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献Structural and Biochemical Characterization of Mycobacterium Tuberculosis Cyp142: Evidence for Multiple Cholesterol 27-Hydroxylase Activities in a Human Pathogen.
J.Biol.Chem., 285, 2010
4J14
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BU of 4j14 by Molmil
Crystal Structure of Human Cytochrome P450 CYP46A1 with Posaconazole Bound
分子名称: Cholesterol 24-hydroxylase, GLYCEROL, POSACONAZOLE, ...
著者Stout, C.D, Mast, N, Pikuleva, I.A.
登録日2013-01-31
公開日2014-01-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1.
Mol.Pharmacol., 84, 2013
4FIA
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BU of 4fia by Molmil
Crystal Structure of Human CYP46A1 P450 with bicalutamide Bound
分子名称: Cholesterol 24-hydroxylase, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Stout, C.D, Pikuleva, I.A, Mast, N.
登録日2012-06-08
公開日2013-01-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response.
J.Biol.Chem., 288, 2013
4ENH
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BU of 4enh by Molmil
Crystal Structure of Human Cytochrome P450 CYP46A1 with Fluvoxamine Bound
分子名称: Cholesterol 24-hydroxylase, Fluvoxamine, PROTOPORPHYRIN IX CONTAINING FE
著者Stout, C.D, Mast, N, Pikuleva, I.A.
登録日2012-04-13
公開日2012-08-22
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献In Silico and Intuitive Predictions of CYP46A1 Inhibition by Marketed Drugs with Subsequent Enzyme Crystallization in Complex with Fluvoxamine.
Mol.Pharmacol., 82, 2012
3MDR
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BU of 3mdr by Molmil
Tranylcypromine complex of Cytochrome P450 46A1
分子名称: (1R,2S)-2-phenylcyclopropanamine, Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE
著者Mast, N, Charvet, C, Pikuleva, I, Stout, C.D.
登録日2010-03-30
公開日2010-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain.
J.Biol.Chem., 285, 2010
3MDT
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BU of 3mdt by Molmil
Voriconazole complex of Cytochrome P450 46A1
分子名称: Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, Voriconazole
著者Mast, N, Charvet, C, Pikuleva, I, Stout, C.D.
登録日2010-03-30
公開日2010-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain.
J.Biol.Chem., 285, 2010
3MDM
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BU of 3mdm by Molmil
Thioperamide complex of Cytochrome P450 46A1
分子名称: Cholesterol 24-hydroxylase, N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide, PROTOPORPHYRIN IX CONTAINING FE
著者Mast, N, Charvet, C, Pikuleva, I, Stout, C.D.
登録日2010-03-30
公開日2010-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain.
J.Biol.Chem., 285, 2010
3MDV
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BU of 3mdv by Molmil
Clotrimazole complex of Cytochrome P450 46A1
分子名称: 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE
著者Mast, N, Charvet, C, Pikuleva, I, Stout, C.D.
登録日2010-03-30
公開日2010-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain.
J.Biol.Chem., 285, 2010
3MZS
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BU of 3mzs by Molmil
Crystal Structure of Cytochrome P450 CYP11A1 in complex with 22-hydroxy-cholesterol
分子名称: (3alpha,8alpha,22R)-cholest-5-ene-3,22-diol, Cholesterol side-chain cleavage enzyme, ISOPROPYL ALCOHOL, ...
著者Stout, C.D, Annalora, A, Mast, N, Pikuleva, I.
登録日2010-05-12
公開日2010-12-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis for Three-step Sequential Catalysis by the Cholesterol Side Chain Cleavage Enzyme CYP11A1.
J.Biol.Chem., 286, 2011
3IVY
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BU of 3ivy by Molmil
Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP125, p212121 crystal form
分子名称: Cytochrome P450 CYP125, PROTOPORPHYRIN IX CONTAINING FE
著者McLean, K.J, Levy, C, Munro, A.W, Leys, D.
登録日2009-09-02
公開日2009-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.352 Å)
主引用文献The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.
J.Biol.Chem., 284, 2009
3IW2
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Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP125 in complex with econazole
分子名称: 4-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, Cytochrome P450 CYP125, PROTOPORPHYRIN IX CONTAINING FE
著者McLean, K.J, Levy, C, Munro, A.W, Leys, D.
登録日2009-09-02
公開日2009-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.
J.Biol.Chem., 284, 2009
3IW0
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BU of 3iw0 by Molmil
Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP125, C2221 crystal form
分子名称: Cytochrome P450 CYP125, PHOSPHATE ION, PROTOPORPHYRIN IX CONTAINING FE
著者McLean, K.J, Levy, C, Munro, A.W, Leys, D.
登録日2009-09-02
公開日2009-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.
J.Biol.Chem., 284, 2009
3IW1
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Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP125 in complex with androstenedione
分子名称: 4-ANDROSTENE-3-17-DIONE, Cytochrome P450 CYP125, PROTOPORPHYRIN IX CONTAINING FE
著者McLean, K.J, Levy, C, Munro, A.W, Leys, D.
登録日2009-09-02
公開日2009-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.
J.Biol.Chem., 284, 2009

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