3MDM
Thioperamide complex of Cytochrome P450 46A1
Summary for 3MDM
| Entry DOI | 10.2210/pdb3mdm/pdb |
| Related | 2Q9F 2Q9G 3MDR 3MDT 3MDV |
| Descriptor | Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide, ... (4 entities in total) |
| Functional Keywords | cyp46a1, p450 46a1, p450, thioperamide, monooxygenase, metabolic enzyme, oxidoreductase, heme, cholesterol metabolism, endoplasmic reticulum, iron, lipid metabolism, membrane, metal-binding, microsome, nadp, steroid metabolism, transmembrane |
| Biological source | Homo sapiens (human) |
| Cellular location | Endoplasmic reticulum membrane; Single-pass membrane protein: Q9Y6A2 |
| Total number of polymer chains | 1 |
| Total formula weight | 53034.02 |
| Authors | Mast, N.,Charvet, C.,Pikuleva, I.,Stout, C.D. (deposition date: 2010-03-30, release date: 2010-07-28, Last modification date: 2023-09-06) |
| Primary citation | Mast, N.,Charvet, C.,Pikuleva, I.A.,Stout, C.D. Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain. J.Biol.Chem., 285:31783-31795, 2010 Cited by PubMed: 20667828DOI: 10.1074/jbc.M110.143313 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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