3MDT

Voriconazole complex of Cytochrome P450 46A1

Summary for 3MDT

Entry DOI	10.2210/pdb3mdt/pdb
Related	2Q9F 2Q9G 3MDM 3MDR 3MDV
Descriptor	Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, Voriconazole, ... (4 entities in total)
Functional Keywords	cyp46a1, p450 46a1, p450, voriconazole, monooxygenase, metabolic enzyme, oxidoreductase, heme, cholesterol metabolism, endoplasmic reticulum, iron, lipid metabolism, membrane, metal-binding, microsome, nadp, steroid metabolism, transmembrane
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: Q9Y6A2
Total number of polymer chains	2
Total formula weight	106181.77
Authors	Mast, N.,Charvet, C.,Pikuleva, I.,Stout, C.D. (deposition date: 2010-03-30, release date: 2010-07-28, Last modification date: 2023-09-06)
Primary citation	Mast, N.,Charvet, C.,Pikuleva, I.A.,Stout, C.D. Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain. J.Biol.Chem., 285:31783-31795, 2010 Cited by PubMed: 20667828 DOI: 10.1074/jbc.M110.143313 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation