2Q9G
Crystal structure of human cytochrome P450 46A1
Summary for 2Q9G
Entry DOI | 10.2210/pdb2q9g/pdb |
Related | 2q9f |
Descriptor | Cytochrome P450 46A1, PROTOPORPHYRIN IX CONTAINING FE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | cyp46a1, p450 46a1, p450, monooxygenase, cholesterol metabolic enzyme, oxidoreductase, heme |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Single-pass membrane protein: Q9Y6A2 |
Total number of polymer chains | 1 |
Total formula weight | 52925.76 |
Authors | White, M.A.,Mast, N.V.,Johnson, E.F.,Stout, C.D.,Pikuleva, I.A. (deposition date: 2007-06-12, release date: 2008-06-17, Last modification date: 2023-08-30) |
Primary citation | Mast, N.,White, M.A.,Bjorkhem, I.,Johnson, E.F.,Stout, C.D.,Pikuleva, I.A. Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain. Proc.Natl.Acad.Sci.Usa, 105:9546-9551, 2008 Cited by PubMed: 18621681DOI: 10.1073/pnas.0803717105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report