3MDR

Tranylcypromine complex of Cytochrome P450 46A1

Summary for 3MDR

Entry DOI	10.2210/pdb3mdr/pdb
Related	2Q9F 2Q9G 3MDM 3MDT 3MDV
Descriptor	Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, (1R,2S)-2-phenylcyclopropanamine, ... (4 entities in total)
Functional Keywords	cyp46a1, p450 46a1, p450, tranylcypromine, monooxygenase, metabolic enzyme, oxidoreductase, heme, cholesterol metabolism, endoplasmic reticulum, iron, lipid metabolism, membrane, metal-binding, microsome, nadp, steroid metabolism, transmembrane
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	105749.53
Authors	Mast, N.,Charvet, C.,Pikuleva, I.,Stout, C.D. (deposition date: 2010-03-30, release date: 2010-07-28, Last modification date: 2023-09-06)
Primary citation	Mast, N.,Charvet, C.,Pikuleva, I.A.,Stout, C.D. Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain. J.Biol.Chem., 285:31783-31795, 2010 Cited by PubMed: 20667828 DOI: 10.1074/jbc.M110.143313 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation