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3MDR

Tranylcypromine complex of Cytochrome P450 46A1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0006699biological_processbile acid biosynthetic process
A0006707biological_processcholesterol catabolic process
A0006805biological_processxenobiotic metabolic process
A0007399biological_processnervous system development
A0008203biological_processcholesterol metabolic process
A0008207biological_processC21-steroid hormone metabolic process
A0008395molecular_functionsteroid hydroxylase activity
A0016020cellular_componentmembrane
A0016125biological_processsterol metabolic process
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0020037molecular_functionheme binding
A0030425cellular_componentdendrite
A0033781molecular_functioncholesterol 24-hydroxylase activity
A0042448biological_processprogesterone metabolic process
A0042995cellular_componentcell projection
A0045202cellular_componentsynapse
A0046872molecular_functionmetal ion binding
A0062184molecular_functiontestosterone 16-beta-hydroxylase activity
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A1900271biological_processregulation of long-term synaptic potentiation
A1903044biological_processprotein localization to membrane raft
B0004497molecular_functionmonooxygenase activity
B0005506molecular_functioniron ion binding
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0006699biological_processbile acid biosynthetic process
B0006707biological_processcholesterol catabolic process
B0006805biological_processxenobiotic metabolic process
B0007399biological_processnervous system development
B0008203biological_processcholesterol metabolic process
B0008207biological_processC21-steroid hormone metabolic process
B0008395molecular_functionsteroid hydroxylase activity
B0016020cellular_componentmembrane
B0016125biological_processsterol metabolic process
B0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B0020037molecular_functionheme binding
B0030425cellular_componentdendrite
B0033781molecular_functioncholesterol 24-hydroxylase activity
B0042448biological_processprogesterone metabolic process
B0042995cellular_componentcell projection
B0045202cellular_componentsynapse
B0046872molecular_functionmetal ion binding
B0062184molecular_functiontestosterone 16-beta-hydroxylase activity
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B1900271biological_processregulation of long-term synaptic potentiation
B1903044biological_processprotein localization to membrane raft
Functional Information from PDB Data
site_idAC1
Number of Residues22
DetailsBINDING SITE FOR RESIDUE HEM A 505
ChainResidue
AHOH7
ASER307
ATHR370
APRO429
APHE430
ASER431
AARG435
ASER436
ACYS437
AGLY439
APHE442
ALYS104
AALA443
AGJZ506
AHOH589
ATYR109
ALEU125
AVAL126
ATRP134
AARG138
AGLY303
ATHR306

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GJZ A 506
ChainResidue
AILE301
AALA302
ATHR306
AHEM505

site_idAC3
Number of Residues25
DetailsBINDING SITE FOR RESIDUE HEM B 505
ChainResidue
BHOH3
BLYS104
BTYR109
BLEU125
BVAL126
BTRP134
BARG138
BPHE299
BALA302
BGLY303
BTHR306
BSER307
BHIS310
BALA367
BTHR370
BPRO429
BPHE430
BARG435
BSER436
BCYS437
BGLY439
BPHE442
BGJZ506
BHOH581
BHOH605

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GJZ B 506
ChainResidue
BPHE121
BILE301
BALA302
BTHR306
BHEM505

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSlGHRSCIG
ChainResidueDetails
APHE430-GLY439

Functional Information from SwissProt/UniProt

219869

PDB entries from 2024-05-15

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