4FIA

Crystal Structure of Human CYP46A1 P450 with bicalutamide Bound

Summary for 4FIA

Entry DOI	10.2210/pdb4fia/pdb
Related	2Q9F
Descriptor	Cholesterol 24-hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, S-bicalutamide, ... (6 entities in total)
Functional Keywords	cytochrome p450, cyp46a1, bicalutamide complex, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: Q9Y6A2
Total number of polymer chains	1
Total formula weight	53694.41
Authors	Stout, C.D.,Pikuleva, I.A.,Mast, N. (deposition date: 2012-06-08, release date: 2013-01-09, Last modification date: 2024-02-28)
Primary citation	Mast, N.,Zheng, W.,Stout, C.D.,Pikuleva, I.A. Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response. J.Biol.Chem., 288:4613-4624, 2013 Cited by PubMed: 23288837 DOI: 10.1074/jbc.M112.438754 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation