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HER2-binding scFv-Fab fusion 841
分子名称:	1,2-ETHANEDIOL, 841 heavy chain, 841 light chain
著者	Kast, F, Schwill, M, Stueber, J.C, Pfundstein, S, Nagy-Davidescu, G, Monne Rodriguez, J.M, Seehusen, F, Richter, C.P, Honegger, A, Hartmann, K.P, Weber, T.G, Kroener, F, Ernst, P, Piehler, J, Plueckthun, A.
登録日	2020-07-09
公開日	2021-06-30
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action. Nat Commun, 12, 2021

2NUB

Structure of Aquifex aeolicus Argonuate
分子名称:	Argonaute
著者	Rashid, U.J, Paterok, D, Koglin, A, Gohlke, H, Piehler, J, Chen, J.C.-H.
登録日	2006-11-09
公開日	2007-02-06
最終更新日	2023-10-25
実験手法	X-RAY DIFFRACTION (3.2 Å)
主引用文献	Structure of Aquifex aeolicus argonaute highlights conformational flexibility of the PAZ domain as a potential regulator of RNA-induced silencing complex function. J.Biol.Chem., 282, 2007

8G04

Structure of signaling thrombopoietin-MPL receptor complex
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombopoietin, Thrombopoietin receptor, ...
著者	Tsutsumi, N, Jude, K.M, Gati, C, Garcia, K.C.
登録日	2023-01-31
公開日	2023-08-30
最終更新日	2024-05-08
実験手法	ELECTRON MICROSCOPY (3.4 Å)
主引用文献	Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis. Cell, 186, 2023

8TLD

Structure of the IL-5 Signaling Complex
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit beta, Interleukin-5, ...
著者	Caveney, N.A, Garcia, K.C.
登録日	2023-07-26
公開日	2024-04-10
実験手法	ELECTRON MICROSCOPY (3.6 Å)
主引用文献	Organizing structural principles of common beta family signaling To Be Published

5E4E

Engineered Interleukin-13 bound to receptor
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-13, Interleukin-13 receptor subunit alpha-1, ...
著者	Moraga, I, Thomas, C, Jude, K.M, Garcia, K.C.
登録日	2015-10-05
公開日	2015-12-02
最終更新日	2020-07-29
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency. Sci.Signal., 8, 2015

7P3Y

Homology model of the full-length AP-3 complex in an intermediate open conformation
分子名称:	AP complex subunit sigma, AP-3 complex subunit delta, AP-3 complex subunit mu, ...
著者	Schubert, E, Raunser, S.
登録日	2021-07-09
公開日	2021-09-29
最終更新日	2024-07-17
実験手法	ELECTRON MICROSCOPY (10.1 Å)
主引用文献	Flexible open conformation of the AP-3 complex explains its role in cargo recruitment at the Golgi. J.Biol.Chem., 297, 2021

7P3X

Homology model of the full-length AP-3 complex in a compact open conformation
分子名称:	AP complex subunit sigma, AP-3 complex subunit delta, AP-3 complex subunit mu, ...
著者	Schubert, E, Raunser, S.
登録日	2021-07-09
公開日	2021-09-29
最終更新日	2024-07-17
実験手法	ELECTRON MICROSCOPY (9.1 Å)
主引用文献	Flexible open conformation of the AP-3 complex explains its role in cargo recruitment at the Golgi. J.Biol.Chem., 297, 2021

7P3Z

Homology model of the full-length AP-3 complex in a stretched open conformation
分子名称:	AP complex subunit sigma, AP-3 complex subunit delta, AP-3 complex subunit mu, ...
著者	Schubert, E, Raunser, S.
登録日	2021-07-09
公開日	2021-09-29
最終更新日	2021-12-08
実験手法	ELECTRON MICROSCOPY (10.5 Å)
主引用文献	Flexible open conformation of the AP-3 complex explains its role in cargo recruitment at the Golgi. J.Biol.Chem., 297, 2021

6E3K

Interferon gamma signalling complex with IFNGR1 and IFNGR2
分子名称:	1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Jude, K.M, Mendoza, J.L, Garcia, K.C.
登録日	2018-07-14
公開日	2019-02-27
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (3.25 Å)
主引用文献	Structure of the IFN gamma receptor complex guides design of biased agonists. Nature, 567, 2019

6E3L

Interferon gamma signalling complex with IFNGR1 and IFNGR2
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, ...
著者	Jude, K.M, Mendoza, J.L, Garcia, K.C.
登録日	2018-07-14
公開日	2019-02-27
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (3.8 Å)
主引用文献	Structure of the IFN gamma receptor complex guides design of biased agonists. Nature, 567, 2019

5UN6

Frizzled-8 complex with designed surrogate Wnt agonist, A1 dataset
分子名称:	Designed Wnt agonist B12, Frizzled-8
著者	Janda, C.Y, Garcia, K.C, Jude, K.M.
登録日	2017-01-30
公開日	2017-05-03
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (3.2 Å)
主引用文献	Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling. Nature, 545, 2017

5UN5

Frizzled-8 complex with designed surrogate Wnt agonist, crystal form 1
分子名称:	Designed Wnt agonist B12, Frizzled-8
著者	Janda, C.Y, Garcia, K.C.
登録日	2017-01-30
公開日	2017-05-03
最終更新日	2024-10-09
実験手法	X-RAY DIFFRACTION (2.994 Å)
主引用文献	Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling. Nature, 545, 2017

7Z3R

Crystal structure of the mouse leptin:LepR-IgCRH2 complex to 2.95 A resolution.
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor
著者	Verstraete, K, Verschueren, K, Savvides, S.N, Tsirigotaki, A.
登録日	2022-03-02
公開日	2023-03-22
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (2.951 Å)
主引用文献	Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023

7Z3P

Crystal structure of the mouse leptin:LepR-CRH2 encounter complex to 1.95 A resolution.
分子名称:	CALCIUM ION, DI(HYDROXYETHYL)ETHER, Leptin, ...
著者	Tsirigotaki, A, Verschueren, K, Savvides, S.N, Verstraete, K.
登録日	2022-03-02
公開日	2023-03-22
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (1.943 Å)
主引用文献	Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023

7Z3Q

Crystal structure of the human leptin:LepR-CRH2 encounter complex to 3.6 A resolution.
分子名称:	Leptin, Leptin receptor
著者	Verstraete, K, Verschueren, K, Alexandra, T, Savvides, S.N.
登録日	2022-03-02
公開日	2023-03-22
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (3.617 Å)
主引用文献	Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023

4Y5X

Diabody 305 complex with EpoR
分子名称:	CITRATE ANION, DI(HYDROXYETHYL)ETHER, Erythropoietin receptor, ...
著者	Moraga, I, Guo, F, Ozkan, E, Jude, K.M, Garcia, K.C.
登録日	2015-02-12
公開日	2015-03-18
最終更新日	2017-11-22
実験手法	X-RAY DIFFRACTION (3.15 Å)
主引用文献	Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands. Cell, 160, 2015

4Y5V

Diabody 305 complex with EpoR
分子名称:	DI(HYDROXYETHYL)ETHER, Diabody 305 VL domain, Erythropoietin receptor, ...
著者	Moraga, I, Guo, F, Ozkan, E, Jude, K.M, Garcia, K.C.
登録日	2015-02-12
公開日	2015-04-29
実験手法	X-RAY DIFFRACTION (2.604 Å)
主引用文献	Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands. Cell, 160, 2015

8QY5

Structure of interleukin 6.
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ...
著者	Gardner, S, Bubeck, D, Jin, Y.
登録日	2023-10-25
公開日	2024-02-21
最終更新日	2024-10-09
実験手法	ELECTRON MICROSCOPY (3.1 Å)
主引用文献	Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency. Nat Commun, 15, 2024

8QY6

Structure of interleukin 6 (gp130 P496L mutant).
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ...
著者	Gardner, S, Bubeck, D, Jin, Y.
登録日	2023-10-25
公開日	2024-02-21
最終更新日	2024-09-04
実験手法	ELECTRON MICROSCOPY (3.16 Å)
主引用文献	Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency. Nat Commun, 15, 2024

4Y5Y

Diabody 330 complex with EpoR
分子名称:	Erythropoietin receptor, GLYCEROL, diabody 330 VH domain, ...
著者	Moraga, I, Guo, F, Ozkan, E, Jude, K.M, Garcia, K.C.
登録日	2015-02-12
公開日	2015-03-18
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.85 Å)
主引用文献	Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands. Cell, 160, 2015

8QY4

Structure of interleukin 11 (gp130 P496L mutant).
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-11, ...
著者	Gardner, S, Bubeck, D, Jin, Y.
登録日	2023-10-25
公開日	2024-02-21
最終更新日	2024-09-04
実験手法	ELECTRON MICROSCOPY (3.06 Å)
主引用文献	Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency. Nat Commun, 15, 2024

8AVD

Cryo-EM structure for a 3:3 complex between mouse leptin and the mouse LEP-R ectodomain (local refinement)
分子名称:	Leptin, Leptin receptor, NICKEL (II) ION
著者	Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日	2022-08-26
公開日	2023-04-05
最終更新日	2023-04-26
実験手法	ELECTRON MICROSCOPY (4.42 Å)
主引用文献	Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023

8AVF

Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (closed 3:3 model)
分子名称:	Leptin, Leptin receptor
著者	Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日	2022-08-26
公開日	2023-04-05
最終更新日	2023-04-26
実験手法	ELECTRON MICROSCOPY (6.45 Å)
主引用文献	Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023

8AVO

Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (open 3:3 model).
分子名称:	Leptin, Leptin receptor
著者	Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日	2022-08-26
公開日	2023-04-05
最終更新日	2024-10-16
実験手法	ELECTRON MICROSCOPY (6.84 Å)
主引用文献	Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023

8AV2

Crystal structure for the FnIII module of mouse LEP-R in complex with the anti-LEP-R nanobody VHH-4.80
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin receptor, SULFATE ION, ...
著者	Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A.
登録日	2022-08-26
公開日	2023-04-05
最終更新日	2024-02-07
実験手法	X-RAY DIFFRACTION (1.75 Å)
主引用文献	Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023

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表示件数:	25
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