6E3L

Interferon gamma signalling complex with IFNGR1 and IFNGR2

Summary for 6E3L

Related6E3K
DescriptorInterferon gamma, Interferon gamma receptor 1, Interferon gamma receptor 2, ... (7 entities in total)
Functional Keywordscytokine receptor, protein complex, protein engineering, cytokine
Biological sourceHomo sapiens (Human)
Total number of polymer chains6
Total molecular weight147487.89
Authors
Jude, K.M.,Mendoza, J.L.,Garcia, K.C. (deposition date: 2018-07-14, release date: 2019-02-27, Last modification date: 2019-03-20)
Primary citation
Mendoza, J.L.,Escalante, N.K.,Jude, K.M.,Sotolongo Bellon, J.,Su, L.,Horton, T.M.,Tsutsumi, N.,Berardinelli, S.J.,Haltiwanger, R.S.,Piehler, J.,Engleman, E.G.,Garcia, K.C.
Structure of the IFN gamma receptor complex guides design of biased agonists.
Nature, 567:56-60, 2019
PubMed: 30814731 (PDB entries with the same primary citation)
DOI: 10.1038/s41586-019-0988-7
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27060 0.6% 14.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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