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6E3L

Interferon gamma signalling complex with IFNGR1 and IFNGR2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001774biological_processmicroglial cell activation
A0001819biological_processpositive regulation of cytokine production
A0002250biological_processadaptive immune response
A0002281biological_processmacrophage activation involved in immune response
A0005125molecular_functioncytokine activity
A0005133molecular_functiontype II interferon receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006915biological_processapoptotic process
A0006955biological_processimmune response
A0006959biological_processhumoral immune response
A0007166biological_processcell surface receptor signaling pathway
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0008284biological_processpositive regulation of cell population proliferation
A0009615biological_processresponse to virus
A0010508biological_processpositive regulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010634biological_processpositive regulation of epithelial cell migration
A0030225biological_processmacrophage differentiation
A0030857biological_processnegative regulation of epithelial cell differentiation
A0032700biological_processnegative regulation of interleukin-17 production
A0032722biological_processpositive regulation of chemokine production
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032735biological_processpositive regulation of interleukin-12 production
A0032747biological_processpositive regulation of interleukin-23 production
A0032755biological_processpositive regulation of interleukin-6 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032834biological_processpositive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
A0033141biological_processpositive regulation of peptidyl-serine phosphorylation of STAT protein
A0034393biological_processpositive regulation of smooth muscle cell apoptotic process
A0038096biological_processFc-gamma receptor signaling pathway involved in phagocytosis
A0038196biological_processtype III interferon-mediated signaling pathway
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0045348biological_processpositive regulation of MHC class II biosynthetic process
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0045672biological_processpositive regulation of osteoclast differentiation
A0045785biological_processpositive regulation of cell adhesion
A0045821biological_processpositive regulation of glycolytic process
A0045892biological_processnegative regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048143biological_processastrocyte activation
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0050729biological_processpositive regulation of inflammatory response
A0050766biological_processpositive regulation of phagocytosis
A0050769biological_processpositive regulation of neurogenesis
A0050796biological_processregulation of insulin secretion
A0051044biological_processpositive regulation of membrane protein ectodomain proteolysis
A0051607biological_processdefense response to virus
A0060333biological_processtype II interferon-mediated signaling pathway
A0060552biological_processpositive regulation of fructose 1,6-bisphosphate metabolic process
A0060557biological_processpositive regulation of vitamin D biosynthetic process
A0097191biological_processextrinsic apoptotic signaling pathway
A0097696biological_processcell surface receptor signaling pathway via STAT
A0098586biological_processcellular response to virus
A0150076biological_processneuroinflammatory response
A1900222biological_processnegative regulation of amyloid-beta clearance
A1900451biological_processpositive regulation of glutamate receptor signaling pathway
A1901857biological_processpositive regulation of cellular respiration
A1902004biological_processpositive regulation of amyloid-beta formation
A1903078biological_processpositive regulation of protein localization to plasma membrane
A1903543biological_processpositive regulation of exosomal secretion
A1904440biological_processpositive regulation of iron ion import across plasma membrane
A2000309biological_processpositive regulation of tumor necrosis factor (ligand) superfamily member 11 production
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0001774biological_processmicroglial cell activation
B0001819biological_processpositive regulation of cytokine production
B0002250biological_processadaptive immune response
B0002281biological_processmacrophage activation involved in immune response
B0005125molecular_functioncytokine activity
B0005133molecular_functiontype II interferon receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006915biological_processapoptotic process
B0006955biological_processimmune response
B0006959biological_processhumoral immune response
B0007166biological_processcell surface receptor signaling pathway
B0007259biological_processcell surface receptor signaling pathway via JAK-STAT
B0008284biological_processpositive regulation of cell population proliferation
B0009615biological_processresponse to virus
B0010508biological_processpositive regulation of autophagy
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010634biological_processpositive regulation of epithelial cell migration
B0030225biological_processmacrophage differentiation
B0030857biological_processnegative regulation of epithelial cell differentiation
B0032700biological_processnegative regulation of interleukin-17 production
B0032722biological_processpositive regulation of chemokine production
B0032731biological_processpositive regulation of interleukin-1 beta production
B0032735biological_processpositive regulation of interleukin-12 production
B0032747biological_processpositive regulation of interleukin-23 production
B0032755biological_processpositive regulation of interleukin-6 production
B0032760biological_processpositive regulation of tumor necrosis factor production
B0032834biological_processpositive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
B0033141biological_processpositive regulation of peptidyl-serine phosphorylation of STAT protein
B0034393biological_processpositive regulation of smooth muscle cell apoptotic process
B0038096biological_processFc-gamma receptor signaling pathway involved in phagocytosis
B0038196biological_processtype III interferon-mediated signaling pathway
B0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
B0045348biological_processpositive regulation of MHC class II biosynthetic process
B0045429biological_processpositive regulation of nitric oxide biosynthetic process
B0045672biological_processpositive regulation of osteoclast differentiation
B0045785biological_processpositive regulation of cell adhesion
B0045821biological_processpositive regulation of glycolytic process
B0045892biological_processnegative regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048143biological_processastrocyte activation
B0048662biological_processnegative regulation of smooth muscle cell proliferation
B0050729biological_processpositive regulation of inflammatory response
B0050766biological_processpositive regulation of phagocytosis
B0050769biological_processpositive regulation of neurogenesis
B0050796biological_processregulation of insulin secretion
B0051044biological_processpositive regulation of membrane protein ectodomain proteolysis
B0051607biological_processdefense response to virus
B0060333biological_processtype II interferon-mediated signaling pathway
B0060552biological_processpositive regulation of fructose 1,6-bisphosphate metabolic process
B0060557biological_processpositive regulation of vitamin D biosynthetic process
B0097191biological_processextrinsic apoptotic signaling pathway
B0097696biological_processcell surface receptor signaling pathway via STAT
B0098586biological_processcellular response to virus
B0150076biological_processneuroinflammatory response
B1900222biological_processnegative regulation of amyloid-beta clearance
B1900451biological_processpositive regulation of glutamate receptor signaling pathway
B1901857biological_processpositive regulation of cellular respiration
B1902004biological_processpositive regulation of amyloid-beta formation
B1903078biological_processpositive regulation of protein localization to plasma membrane
B1903543biological_processpositive regulation of exosomal secretion
B1904440biological_processpositive regulation of iron ion import across plasma membrane
B2000309biological_processpositive regulation of tumor necrosis factor (ligand) superfamily member 11 production
C0004896molecular_functioncytokine receptor activity
C0060333biological_processtype II interferon-mediated signaling pathway
D0004896molecular_functioncytokine receptor activity
D0060333biological_processtype II interferon-mediated signaling pathway
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsModified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"3109913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6427223","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"6427223","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine; in dimeric form","evidences":[{"source":"PubMed","id":"6427223","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues9
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues196
DetailsDomain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues196
DetailsDomain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues12
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27599734","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

244349

PDB entries from 2025-11-05

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