6ZQK

HER2-binding scFv-Fab fusion 841

Summary for 6ZQK

Entry DOI	10.2210/pdb6zqk/pdb
Descriptor	841 heavy chain, 841 light chain, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	antibody, her2, scfv-fab fusion, antitumor protein
Biological source	Mus musculus More
Total number of polymer chains	4
Total formula weight	149779.84
Authors	Kast, F.,Schwill, M.,Stueber, J.C.,Pfundstein, S.,Nagy-Davidescu, G.,Monne Rodriguez, J.M.,Seehusen, F.,Richter, C.P.,Honegger, A.,Hartmann, K.P.,Weber, T.G.,Kroener, F.,Ernst, P.,Piehler, J.,Plueckthun, A. (deposition date: 2020-07-09, release date: 2021-06-30, Last modification date: 2024-01-31)
Primary citation	Kast, F.,Schwill, M.,Stuber, J.C.,Pfundstein, S.,Nagy-Davidescu, G.,Rodriguez, J.M.M.,Seehusen, F.,Richter, C.P.,Honegger, A.,Hartmann, K.P.,Weber, T.G.,Kroener, F.,Ernst, P.,Piehler, J.,Pluckthun, A. Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action. Nat Commun, 12:3790-3790, 2021 Cited by PubMed: 34145240 DOI: 10.1038/s41467-021-23948-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation