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2A9M
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BU of 2a9m by Molmil
Structural Analysis of a Tight-binding Fluorescein-scFv; apo form
Descriptor: fluorescein-scfv heavy chain, fluorescein-scfv light chain
Authors:Cambillau, C, Spinelli, S, Honegger, A, Pluckthun, A.
Deposit date:2005-07-12
Release date:2005-10-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A mutation designed to alter crystal packing permits structural analysis of a tight-binding fluorescein-scFv complex.
Protein Sci., 14, 2005
2A9N
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BU of 2a9n by Molmil
A Mutation Designed to Alter Crystal Packing Permits Structural Analysis of a Tight-binding Fluorescein-scFv complex
Descriptor: 4-(2,7-DIFLUORO-6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)ISOPHTHALIC ACID, fluorescein-scfv heavy chain, fluorescein-scfv light chain
Authors:Cambillau, C, Spinelli, S, Honegger, A, Pluckthun, A.
Deposit date:2005-07-12
Release date:2005-10-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:A mutation designed to alter crystal packing permits structural analysis of a tight-binding fluorescein-scFv complex.
Protein Sci., 14, 2005
1C12
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BU of 1c12 by Molmil
INSIGHT IN ODORANT PERCEPTION: THE CRYSTAL STRUCTURE AND BINDING CHARACTERISTICS OF ANTIBODY FRAGMENTS DIRECTED AGAINST THE MUSK ODORANT TRASEOLIDE
Descriptor: PROTEIN (ANTIBODY FRAGMENT FAB), TRAZEOLIDE
Authors:Langedijk, A.C, Spinelli, S, Anguille, C, Hermans, P, Nederlof, J, Butenandt, J, Honegger, A, Cambillau, C, Pluckthun, A.
Deposit date:1999-07-20
Release date:1999-08-14
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insight into odorant perception: the crystal structure and binding characteristics of antibody fragments directed against the musk odorant traseolide.
J.Mol.Biol., 292, 1999
6EQC
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BU of 6eqc by Molmil
Cryo-EM reconstruction of a complex of a binding protein and human adenovirus C5 hexon
Descriptor: Hexon protein, scFv of 9C12 antibody
Authors:Schmid, M, Ernst, P, Honegger, A, Suomalainen, M, Zimmermann, M, Braun, L, Stauffer, S, Thom, C, Dreier, B, Eibauer, M, Kipar, A, Vogel, V, Greber, U.F, Medalia, O, Plueckthun, A.
Deposit date:2017-10-12
Release date:2018-02-07
Last modified:2018-02-14
Method:ELECTRON MICROSCOPY (7.4 Å)
Cite:Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.
Nat Commun, 9, 2018
6F5E
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BU of 6f5e by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DD_D12_10_47 in complex JNK1a1 and JIP1 peptide
Descriptor: C-Jun-amino-terminal kinase-interacting protein 1, DD_D12_10_47, Mitogen-activated protein kinase 8
Authors:Wu, Y, Mittl, P.R, Honegger, A, Batyuk, A, Plueckthun, A.
Deposit date:2017-12-01
Release date:2017-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of DARPin-DARPin rigid fusion, variant DD_D12_10_47 in complex JNK1a1 and JIP1 peptide
To be published
5OGI
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BU of 5ogi by Molmil
Complex of a binding protein and human adenovirus C 5 hexon
Descriptor: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Schmid, M, Ernst, P, Honegger, A, Suomalainen, M, Zimmermann, M, Braun, L, Stauffer, S, Thom, C, Dreier, B, Eibauer, M, Kipar, A, Vogel, V, Greber, U.F, Medalia, O, Plueckthun, A.
Deposit date:2017-07-13
Release date:2018-02-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.
Nat Commun, 9, 2018
6SA7
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BU of 6sa7 by Molmil
DARPin-Armadillo fusion C8long83
Descriptor: DARPin-Armadillo fusion C8long83
Authors:Ernst, P, Honegger, A, van der Valk, F, Ewald, C, Mittl, P.R.E, Plucktun, A.
Deposit date:2019-07-16
Release date:2019-11-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts.
Sci Rep, 9, 2019
6SA8
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ring-like DARPin-Armadillo fusion H83_D01
Descriptor: 1,2-ETHANEDIOL, LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG-LYS-ARG, ring-like DARPin-Armadillo fusion H83_D01
Authors:Ernst, P, Honegger, A, van der Valk, F, Ewald, C, Mittl, P.R.E, Plucktun, A.
Deposit date:2019-07-16
Release date:2019-11-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts.
Sci Rep, 9, 2019
1KTR
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BU of 1ktr by Molmil
Crystal Structure of the Anti-His Tag Antibody 3D5 Single-Chain Fragment (scFv) in Complex with a Oligohistidine peptide
Descriptor: Anti-his tag antibody 3d5 variable light chain, Peptide linker, Anti-his tag antibody 3d5 variable heavy chain, ...
Authors:Kaufmann, M, Lindner, P, Honegger, A, Blank, K, Tschopp, M, Capitani, G, Plueckthun, A, Gruetter, M.G.
Deposit date:2002-01-17
Release date:2002-05-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the anti-His tag antibody 3D5 single-chain fragment complexed to its antigen.
J.Mol.Biol., 318, 2002
4D49
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BU of 4d49 by Molmil
Crystal structure of computationally designed armadillo repeat proteins for modular peptide recognition.
Descriptor: ARGININE, ARMADILLO REPEAT PROTEIN ARM00027, POLY ARG DECAPEPTIDE
Authors:Reichen, C, Forzani, C, Zhou, T, Parmeggiani, F, Fleishman, S.J, Mittl, P.R.E, Madhurantakam, C, Honegger, A, Ewald, C, Zerbe, O, Baker, D, Caflisch, A, Pluckthun, A.
Deposit date:2014-10-27
Release date:2016-01-13
Last modified:2016-11-09
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition.
J.Mol.Biol., 428, 2016
4D4E
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BU of 4d4e by Molmil
Crystal structure of computationally designed armadillo repeat proteins for modular peptide recognition.
Descriptor: ARMADILLO REPEAT PROTEIN ARM00016, GLYCEROL
Authors:Reichen, C, Forzani, C, Zhou, T, Parmeggiani, F, Fleishman, S.J, Mittl, P.R.E, Madhurantakam, C, Honegger, A, Ewald, C, Zerbe, O, Baker, D, Caflisch, A, Pluckthun, A.
Deposit date:2014-10-28
Release date:2016-01-13
Last modified:2016-11-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition.
J.Mol.Biol., 428, 2016
6SA6
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BU of 6sa6 by Molmil
DARPin-Armadillo fusion A5
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DARPin-Armadillo fusion A5
Authors:Ernst, P, Honegger, A, van der Valk, F, Ewald, C, Mittl, P.R.E, Pluckthun, A.
Deposit date:2019-07-16
Release date:2019-11-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Rigid fusions of designed helical repeat binding proteins efficiently protect a binding surface from crystal contacts.
Sci Rep, 9, 2019
1H8S
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BU of 1h8s by Molmil
Three-dimensional structure of anti-ampicillin single chain Fv fragment complexed with the hapten.
Descriptor: (2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, MUTANT AL2 6E7P9G, SULFATE ION
Authors:Burmester, J, Spinelli, S, Pugliese, L, Krebber, A, Honegger, A, Jung, S, Schimmele, B, Cambillau, C, Pluckthun, A.
Deposit date:2001-02-15
Release date:2001-08-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selection, Characterization and X-Ray Structure of Anti-Ampicillin Single-Chain Fv Fragments from Phage-Displayed Murine Antibody Libraries
J.Mol.Biol., 309, 2001
1H8O
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BU of 1h8o by Molmil
Three-dimensional structure of anti-ampicillin single chain Fv fragment.
Descriptor: MUTANT AL2 6E7P9G, SULFATE ION
Authors:Burmester, J, Spinelli, S, Pugliese, L, Krebber, A, Honegger, A, Jung, S, Schimmele, B, Cambillau, C, Pluckthun, A.
Deposit date:2001-02-14
Release date:2001-08-02
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Selection, Characterization and X-Ray Structure of Anti-Ampicillin Single-Chain Fv Fragments from Phage-Displayed Murine Antibody Libraries
J.Mol.Biol., 309, 2001
1I3G
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BU of 1i3g by Molmil
CRYSTAL STRUCTURE OF AN AMPICILLIN SINGLE CHAIN FV, FORM 1, FREE
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ANTIBODY FV FRAGMENT
Authors:Jung, S, Spinelli, S, Schimmele, B, Honegger, A, Pugliese, L, Cambillau, C, Pluckthun, A.
Deposit date:2001-02-15
Release date:2001-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Selection, characterization and x-ray structure of anti-ampicillin single-chain Fv fragments from phage-displayed murine antibody libraries.
J.Mol.Biol., 309, 2001
5AQB
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BU of 5aqb by Molmil
DARPin-based Crystallization Chaperones exploit Molecular Geometry as a Screening Dimension in Protein Crystallography
Descriptor: 3G61_DB15V4, GREEN FLUORESCENT PROTEIN
Authors:Batyuk, A, Wu, Y, Honegger, A, Heberling, M, Plueckthun, A.
Deposit date:2015-09-21
Release date:2016-03-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Darpin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography
J.Mol.Biol., 428, 2016
1H8N
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BU of 1h8n by Molmil
Three-dimensional structure of anti-ampicillin single chain Fv fragment from phage-displayed murine antibody libraries
Descriptor: GLYCEROL, MUTANT AL2 6E7S9G, SULFATE ION
Authors:Jung, S, Spinelli, S, Schimmele, B, Honegger, A, Pugliese, L, Cambillau, C, Pluckthun, A.
Deposit date:2001-02-14
Release date:2001-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The Importance of Framework Residues H6, H7 and H10 in Antibody Heavy Chains: Experimental Evidence for a New Structural Subclassification of Antibody V(H) Domains
J.Mol.Biol., 309, 2001
5AQ9
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BU of 5aq9 by Molmil
DARPin-based Crystallization Chaperones exploit Molecular Geometry as a Screening Dimension in Protein Crystallography
Descriptor: MALTOSE-BINDING PERIPLASMIC PROTEIN, OFF7_DB08V4
Authors:Batyuk, A, Wu, Y, Honegger, A, Heberling, M, Plueckthun, A.
Deposit date:2015-09-21
Release date:2016-03-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Darpin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography
J.Mol.Biol., 428, 2016
5AQA
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BU of 5aqa by Molmil
DARPin-based Crystallization Chaperones exploit Molecular Geometry as a Screening Dimension in Protein Crystallography
Descriptor: OFF7_DB04V3, THIOCYANATE ION
Authors:Batyuk, A, Wu, Y, Honegger, A, Heberling, M, Plueckthun, A.
Deposit date:2015-09-21
Release date:2016-03-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Darpin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography
J.Mol.Biol., 428, 2016
5AQ7
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BU of 5aq7 by Molmil
DARPin-based Crystallization Chaperones exploit Molecular Geometry as a Screening Dimension in Protein Crystallography
Descriptor: D12_DB04V3, MALONATE ION
Authors:Batyuk, A, Wu, Y, Honegger, A, Heberling, M, Plueckthun, A.
Deposit date:2015-09-21
Release date:2016-03-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Darpin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography
J.Mol.Biol., 428, 2016
5AQ8
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BU of 5aq8 by Molmil
DARPin-based Crystallization Chaperones exploit Molecular Geometry as a Screening Dimension in Protein Crystallography
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, OFF7_DB12V4, THIOCYANATE ION
Authors:Batyuk, A, Wu, Y, Honegger, A, Heberling, M, Plueckthun, A.
Deposit date:2015-09-21
Release date:2016-03-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Darpin-Based Crystallization Chaperones Exploit Molecular Geometry as a Screening Dimension in Protein Crystallography
J.Mol.Biol., 428, 2016
5FIO
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BU of 5fio by Molmil
DARPins as a new tool for experimental phasing in protein crystallography
Descriptor: MALTOSE-BINDING PERIPLASMIC PROTEIN, MERCURY (II) ION, NI3C DARPIN MUTANT5 HG-SITE N1
Authors:Batyuk, A, Honegger, A, Andres, F, Briand, C, Gruetter, M, Plueckthun, A.
Deposit date:2015-09-30
Release date:2016-11-16
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Darpins as a New Tool for Experimental Phasing in Protein Crystallography
To be Published
5FIN
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BU of 5fin by Molmil
DARPins as a new tool for experimental phasing in protein crystallography
Descriptor: MERCURY (II) ION, NI3C DARPIN MUTANT5 HG-SITE N1
Authors:Batyuk, A, Honegger, A, Andres, F, Briand, C, Gruetter, M, Plueckthun, A.
Deposit date:2015-09-30
Release date:2016-11-16
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Darpins as a New Tool for Experimental Phasing in Protein Crystallography
To be Published
6ZQK
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BU of 6zqk by Molmil
HER2-binding scFv-Fab fusion 841
Descriptor: 1,2-ETHANEDIOL, 841 heavy chain, 841 light chain
Authors:Kast, F, Schwill, M, Stueber, J.C, Pfundstein, S, Nagy-Davidescu, G, Monne Rodriguez, J.M, Seehusen, F, Richter, C.P, Honegger, A, Hartmann, K.P, Weber, T.G, Kroener, F, Ernst, P, Piehler, J, Plueckthun, A.
Deposit date:2020-07-09
Release date:2021-06-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action.
Nat Commun, 12, 2021
5LW1
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BU of 5lw1 by Molmil
Crystal structure of DARPin-DARPin rigid fusion, variant DD_232_11_D12 in complex JNK1a1 and JIP1 peptide
Descriptor: ADENOSINE, C-Jun-amino-terminal kinase-interacting protein 1, DD_232_11_D12, ...
Authors:Wu, Y, Batyuk, A, Mittl, P.R, Honegger, A, Plueckthun, A.
Deposit date:2016-09-15
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Basis for the Selective Inhibition of c-Jun N-Terminal Kinase 1 Determined by Rigid DARPin-DARPin Fusions.
J.Mol.Biol., 430, 2018

 

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