7Z3P

Crystal structure of the mouse leptin:LepR-CRH2 encounter complex to 1.95 A resolution.

Summary for 7Z3P

Entry DOI	10.2210/pdb7z3p/pdb
Descriptor	Leptin, Leptin receptor, CALCIUM ION, ... (5 entities in total)
Functional Keywords	leptin, obesity, leptin receptor, lepr, adipose tissue, hypothalamus, immune system, cytokine
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	2
Total formula weight	43525.42
Authors	Tsirigotaki, A.,Verschueren, K.,Savvides, S.N.,Verstraete, K. (deposition date: 2022-03-02, release date: 2023-03-22, Last modification date: 2024-02-07)
Primary citation	Tsirigotaki, A.,Dansercoer, A.,Verschueren, K.H.G.,Markovic, I.,Pollmann, C.,Hafer, M.,Felix, J.,Birck, C.,Van Putte, W.,Catteeuw, D.,Tavernier, J.,Fernando Bazan, J.,Piehler, J.,Savvides, S.N.,Verstraete, K. Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30:551-563, 2023 Cited by PubMed: 36959263 DOI: 10.1038/s41594-023-00941-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.943 Å)

Structure validation