1BF8
 
 | | PERIPLASMIC CHAPERONE FIMC, NMR, 20 STRUCTURES | | 分子名称: | CHAPERONE PROTEIN FIMC | | 著者 | Pellecchia, M, Guntert, P, Glockshuber, R, Wuthrich, K. | | 登録日 | 1998-05-28 | | 公開日 | 1998-11-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR solution structure of the periplasmic chaperone FimC.
Nat.Struct.Biol., 5, 1998
|
|
1DG4
 | | NMR STRUCTURE OF THE SUBSTRATE BINDING DOMAIN OF DNAK IN THE APO FORM | | 分子名称: | DNAK | | 著者 | Pellecchia, M, Montgomery, D.L, Stevens, S.Y, Van der Kooi, C.W, Feng, H, Gierasch, L.M, Zuiderweg, E.R.P. | | 登録日 | 1999-11-23 | | 公開日 | 1999-12-08 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural insights into substrate binding by the molecular chaperone DnaK.
Nat.Struct.Biol., 7, 2000
|
|
1XBL
 | | NMR STRUCTURE OF THE J-DOMAIN (RESIDUES 2-76) IN THE ESCHERICHIA COLI N-TERMINAL FRAGMENT (RESIDUES 2-108) OF THE MOLECULAR CHAPERONE DNAJ, 20 STRUCTURES | | 分子名称: | DNAJ | | 著者 | Pellecchia, M, Szyperski, T, Wall, D, Georgopoulos, C, Wuthrich, K. | | 登録日 | 1996-10-07 | | 公開日 | 1997-01-11 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structure of the J-domain and the Gly/Phe-rich region of the Escherichia coli DnaJ chaperone.
J.Mol.Biol., 260, 1996
|
|
6VBX
 | | Crystal structure of Mcl-1 in complex with 138E12 peptide, Lys-covalent antagonist | | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1, Synthetic peptide | | 著者 | Pellecchia, M, Perry, J.J, Kenjic, N, Assar, Z. | | 登録日 | 2019-12-19 | | 公開日 | 2020-12-30 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Design, Synthesis, and Structural Characterization of Lysine Covalent BH3 Peptides Targeting Mcl-1.
J.Med.Chem., 64, 2021
|
|
8VJP
 | | Histidine-covalent stapled alpha-helical peptide (155H1) targeting hMcl-1 | | 分子名称: | (4Z)-oct-4-en-1-ol, (S~1~R)-3-carbamoyl-4-methoxybenzene-1-sulfinic acid, Histidine-covalent stapled alpha-helical peptide, ... | | 著者 | Muzzarelli, K.M, Assar, Z, Alboreggia, G, Pellecchia, M. | | 登録日 | 2024-01-07 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl-1.
J.Med.Chem., 67, 2024
|
|
2FNB
 | | NMR STRUCTURE OF THE FIBRONECTIN ED-B DOMAIN, NMR, 20 STRUCTURES | | 分子名称: | PROTEIN (FIBRONECTIN) | | 著者 | Fattorusso, R, Pellecchia, M, Viti, F, Neri, P, Neri, D, Wuthrich, K. | | 登録日 | 1998-12-16 | | 公開日 | 1998-12-23 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structure of the human oncofoetal fibronectin ED-B domain, a specific marker for angiogenesis.
Structure Fold.Des., 7, 1999
|
|
8GH7
 | | 142D6 bound to BIR3-XIAP | | 分子名称: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, BIR3 inhibitor MAA-CHG-PRO-ZHW, E3 ubiquitin-protein ligase XIAP, ... | | 著者 | Garza-Granados, A, McGuire, J, Baggio, C, Pellecchia, M, Pegan, S.D. | | 登録日 | 2023-03-09 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-07-12 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist.
J.Med.Chem., 66, 2023
|
|
6RJP
 | | Bfl-1 in complex with alpha helical peptide | | 分子名称: | Bcl-2-like protein 11, Bcl-2-related protein A1 | | 著者 | Baggio, C, Gambini, L, Udompholkul, P, Salem, A.F, Hakansson, M, Jossart, J, Perry, J, Pellecchia, M. | | 登録日 | 2019-04-29 | | 公開日 | 2019-10-30 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | N-locking stabilization of covalent helical peptides: Application to Bfl-1 antagonists.
Chem.Biol.Drug Des., 95, 2020
|
|
7OFV
 | | NMR-guided design of potent and selective EphA4 agonistic ligands | | 分子名称: | ACETATE ION, EphA4 agonist ligand, Ephrin type-A receptor 4 | | 著者 | Ganichkin, O.M, Craig, T.K, Baggio, C, Pellecchia, M. | | 登録日 | 2021-05-05 | | 公開日 | 2021-08-11 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands.
J.Med.Chem., 64, 2021
|
|
2A26
 | | Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein | | 分子名称: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Calcyclin-binding protein, SULFATE ION | | 著者 | Santelli, E, Leone, M, Li, C, Fukushima, T, Preece, N.E, Olson, A.J, Ely, K.R, Reed, J.C, Pellecchia, M, Liddington, R.C, Matsuzawa, S. | | 登録日 | 2005-06-21 | | 公開日 | 2005-08-09 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Structural Analysis of Siah1-Siah-interacting Protein Interactions and Insights into the Assembly of an E3 Ligase Multiprotein Complex
J.Biol.Chem., 280, 2005
|
|
1Q5L
 | | NMR structure of the substrate binding domain of DnaK bound to the peptide NRLLLTG | | 分子名称: | Chaperone protein dnaK, peptide NRLLLTG | | 著者 | Stevens, S.Y, Cai, S, Pellecchia, M, Zuiderweg, E.R. | | 登録日 | 2003-08-08 | | 公開日 | 2003-11-04 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The solution structure of the bacterial HSP70 chaperone protein domain DnaK(393-507) in complex with the peptide NRLLLTG.
Protein Sci., 12, 2003
|
|
2A25
 | | Crystal structure of Siah1 SBD bound to the peptide EKPAAVVAPITTG from SIP | | 分子名称: | Calcyclin-binding protein peptide, Ubiquitin ligase SIAH1, ZINC ION | | 著者 | Santelli, E, Leone, M, Li, C, Fukushima, T, Preece, N.E, Olson, A.J, Ely, K.R, Reed, J.C, Pellecchia, M, Liddington, R.C, Matsuzawa, S. | | 登録日 | 2005-06-21 | | 公開日 | 2005-08-09 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural Analysis of Siah1-Siah-interacting Protein Interactions and Insights into the Assembly of an E3 Ligase Multiprotein Complex
J.Biol.Chem., 280, 2005
|
|
2GAQ
 | |
2KG5
 | | NMR Solution structure of ARAP3-SAM | | 分子名称: | Arf-GAP, Rho-GAP domain, ANK repeat and PH domain-containing protein 3 | | 著者 | Leone, M, Pellecchia, M. | | 登録日 | 2009-03-05 | | 公開日 | 2009-11-17 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Sam domain of the lipid phosphatase Ship2 adopts a common model to interact with Arap3-Sam and EphA2-Sam.
Bmc Struct.Biol., 9, 2009
|
|
2K4P
 | | Solution Structure of Ship2-Sam | | 分子名称: | Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 | | 著者 | Leone, M, Pellecchia, M. | | 登録日 | 2008-06-16 | | 公開日 | 2008-11-25 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR Studies of a Heterotypic Sam-Sam Domain Association: The Interaction between the Lipid Phosphatase Ship2 and the EphA2 Receptor.
Biochemistry, 47, 2008
|
|
2GJY
 | |
4I7B
 | | Siah1 bound to synthetic peptide (ACE)KLRPV(ABA)MVRPTVR | | 分子名称: | E3 ubiquitin-protein ligase SIAH1, Protein phyllopod, ZINC ION | | 著者 | Santelli, E, Stebbins, J.L, Feng, Y, De, S.K, Purves, A, Motamedchaboki, K, Wu, B, Ronai, Z.A, Liddington, R.C, Pellecchia, M. | | 登録日 | 2012-11-30 | | 公開日 | 2013-08-14 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure-based design of covalent siah inhibitors.
Chem.Biol., 20, 2013
|
|
4I7D
 | | Siah1 bound to synthetic peptide (ACE)KLRPVAMVRP(PRK)VR | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase SIAH1, Protein phyllopod, ... | | 著者 | Santelli, E, Stebbins, J.L, Feng, Y, De, S.K, Purves, A, Motamedchaboki, K, Wu, B, Ronai, Z.A, Liddington, R.C, Pellecchia, M. | | 登録日 | 2012-11-30 | | 公開日 | 2013-08-14 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure-based design of covalent siah inhibitors.
Chem.Biol., 20, 2013
|
|
4I7C
 | | Siah1 mutant bound to synthetic peptide (ACE)KLRPV(23P)MVRPWVR | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase SIAH1, Protein phyllopod, ... | | 著者 | Santelli, E, Stebbins, J.L, Feng, Y, De, S.K, Purves, A, Motamedchaboki, K, Wu, B, Ronai, Z.A, Liddington, R.C, Pellecchia, M. | | 登録日 | 2012-11-30 | | 公開日 | 2013-08-14 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure-based design of covalent siah inhibitors.
Chem.Biol., 20, 2013
|
|
2LWK
 | | Solution structure of small molecule-influenza RNA complex | | 分子名称: | 6,7-dimethoxy-2-(piperazin-1-yl)quinazolin-4-amine, RNA (32-MER) | | 著者 | Lee, M.-K, Varani, G, Choi, B.-S, Pellecchia, M, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | 登録日 | 2012-08-01 | | 公開日 | 2012-08-29 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.
Chem.Commun.(Camb.), 50, 2014
|
|
2LK1
 | |
2LK0
 | |
3F81
 | | Interaction of VHR with SA3 | | 分子名称: | 2-[(5~{E})-5-[[3-[4-(2-fluoranylphenoxy)phenyl]-1-phenyl-pyrazol-4-yl]methylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanesulfonic acid, Dual specificity protein phosphatase 3 | | 著者 | Wu, S, Mutelin, T, Tautz, L. | | 登録日 | 2008-11-11 | | 公開日 | 2009-11-10 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.
J.Med.Chem., 52, 2009
|
|
6B9L
 | | Crystal structure of EphA2 with peptide 135E2 | | 分子名称: | Ephrin type-A receptor 2, HIS TAG CLEAVED OFF, peptide 135E2, ... | | 著者 | Song, J, Tan, X. | | 登録日 | 2017-10-10 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structure-Based Design of Novel EphA2 Agonistic Agents with Nanomolar Affinity in Vitro and in Cell.
ACS Chem. Biol., 13, 2018
|
|
1ZXV
 | |
