8GH7
142D6 bound to BIR3-XIAP
Summary for 8GH7
| Entry DOI | 10.2210/pdb8gh7/pdb |
| Related PRD ID | PRD_002528 |
| Descriptor | E3 ubiquitin-protein ligase XIAP, BIR3 inhibitor MAA-CHG-PRO-ZHW, ZINC ION, ... (5 entities in total) |
| Functional Keywords | bir domain, protein-ligand complex, bir3 inhibitor, zinc finger motif, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 24596.31 |
| Authors | Garza-Granados, A.,McGuire, J.,Baggio, C.,Pellecchia, M.,Pegan, S.D. (deposition date: 2023-03-09, release date: 2023-07-05, Last modification date: 2023-07-12) |
| Primary citation | Udompholkul, P.,Garza-Granados, A.,Alboreggia, G.,Baggio, C.,McGuire, J.,Pegan, S.D.,Pellecchia, M. Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist. J.Med.Chem., 66:8159-8169, 2023 Cited by PubMed: 37262387DOI: 10.1021/acs.jmedchem.3c00467 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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