6RJP

Bfl-1 in complex with alpha helical peptide

Summary for 6RJP

Entry DOI	10.2210/pdb6rjp/pdb
Descriptor	Bcl-2-related protein A1, Bcl-2-like protein 11 (3 entities in total)
Functional Keywords	protein-protein interactions, stapled alpha helix, covalent inhibitor, bcl2-2 family proteins, peptide binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	43226.85
Authors	Baggio, C.,Gambini, L.,Udompholkul, P.,Salem, A.F.,Hakansson, M.,Jossart, J.,Perry, J.,Pellecchia, M. (deposition date: 2019-04-29, release date: 2019-10-30, Last modification date: 2024-01-24)
Primary citation	Baggio, C.,Udompholkul, P.,Gambini, L.,Jossart, J.,Salem, A.F.,Hakansson, M.,Perry, J.J.P.,Pellecchia, M. N-locking stabilization of covalent helical peptides: Application to Bfl-1 antagonists. Chem.Biol.Drug Des., 95:412-426, 2020 Cited by PubMed: 31898401 DOI: 10.1111/cbdd.13661 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.57 Å)

Structure validation