2A25

Crystal structure of Siah1 SBD bound to the peptide EKPAAVVAPITTG from SIP

Summary for 2A25

Related1k2f 2a26
DescriptorUbiquitin ligase SIAH1, Calcyclin-binding protein peptide, ZINC ION, ... (4 entities in total)
Functional Keywordsprotein-peptide complex, ligase
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm Q8IUQ4
Nucleus Q9HB71
Total number of polymer chains2
Total molecular weight23013.68
Authors
Santelli, E.,Leone, M.,Li, C.,Fukushima, T.,Preece, N.E.,Olson, A.J.,Ely, K.R.,Reed, J.C.,Pellecchia, M.,Liddington, R.C.,Matsuzawa, S. (deposition date: 2005-06-21, release date: 2005-08-09, Last modification date: 2011-07-13)
Primary citation
Santelli, E.,Leone, M.,Li, C.,Fukushima, T.,Preece, N.E.,Olson, A.J.,Ely, K.R.,Reed, J.C.,Pellecchia, M.,Liddington, R.C.,Matsuzawa, S.
Structural Analysis of Siah1-Siah-interacting Protein Interactions and Insights into the Assembly of an E3 Ligase Multiprotein Complex
J.Biol.Chem., 280:34278-34287, 2005
PubMed: 16085652 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M506707200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24010 0.7% 10.4% 2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171588
PDB entries from 2020-11-25