2A25

Crystal structure of Siah1 SBD bound to the peptide EKPAAVVAPITTG from SIP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0007275	biological_process	multicellular organism development
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 601

Chain	Residue
A	CYS128
A	CYS135
A	HIS147
A	HIS152

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	ZN_FING: SIAH-type => ECO:0000255|PROSITE-ProRule:PRU00455

Chain	Residue	Details
A	SER93-LYS153

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:28546513, ECO:0007744|PDB:5WZZ

Chain	Residue	Details
A	CYS98
A	CYS105
A	HIS117
A	CYS121

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:16085652, ECO:0000269|PubMed:28546513, ECO:0007744|PDB:2A25, ECO:0007744|PDB:5WZZ

Chain	Residue	Details
A	CYS128
A	CYS135
A	HIS147
A	HIS152

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