2A25
| Crystal structure of Siah1 SBD bound to the peptide EKPAAVVAPITTG from SIP | Descriptor: | Calcyclin-binding protein peptide, Ubiquitin ligase SIAH1, ZINC ION | Authors: | Santelli, E, Leone, M, Li, C, Fukushima, T, Preece, N.E, Olson, A.J, Ely, K.R, Reed, J.C, Pellecchia, M, Liddington, R.C, Matsuzawa, S. | Deposit date: | 2005-06-21 | Release date: | 2005-08-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Analysis of Siah1-Siah-interacting Protein Interactions and Insights into the Assembly of an E3 Ligase Multiprotein Complex J.Biol.Chem., 280, 2005
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2A26
| Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Calcyclin-binding protein, SULFATE ION | Authors: | Santelli, E, Leone, M, Li, C, Fukushima, T, Preece, N.E, Olson, A.J, Ely, K.R, Reed, J.C, Pellecchia, M, Liddington, R.C, Matsuzawa, S. | Deposit date: | 2005-06-21 | Release date: | 2005-08-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structural Analysis of Siah1-Siah-interacting Protein Interactions and Insights into the Assembly of an E3 Ligase Multiprotein Complex J.Biol.Chem., 280, 2005
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1RF3
| Structurally Distinct Recognition Motifs in Lymphotoxin-B Receptor and CD40 for TRAF-mediated Signaling | Descriptor: | 24-residue peptide from Lymphotoxin-B Receptor, TNF receptor associated factor 3 | Authors: | Li, C, Norris, P.S, Ni, C.Z, Havert, M.L, Chiong, E.M, Tran, B.R, Cabezas, E, Cheng, G, Reed, J.C, Satterthwait, A.C, Ware, C.F, Ely, K.R. | Deposit date: | 2003-11-07 | Release date: | 2004-07-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling. J.Biol.Chem., 278, 2003
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1I6Z
| BAG DOMAIN OF BAG1 COCHAPERONE | Descriptor: | BAG-FAMILY MOLECULAR CHAPERONE REGULATOR-1 | Authors: | Briknarova, K, Takayama, S, Brive, L, Havert, M.L, Knee, D.A, Velasco, J, Homma, S, Cabezas, E, Stuart, J, Hoyt, D.W, Satterthwait, A.C, Llinas, M, Reed, J.C, Ely, K.R. | Deposit date: | 2001-03-06 | Release date: | 2001-09-06 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural analysis of BAG1 cochaperone and its interactions with Hsc70 heat shock protein. Nat.Struct.Biol., 8, 2001
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1YSX
| Solution structure of domain 3 from human serum albumin complexed to an anti-apoptotic ligand directed against Bcl-xL and Bcl-2 | Descriptor: | 4-({2-[(2,4-DIMETHYLPHENYL)SULFANYL]ETHYL}AMINO)-N-[(4'-FLUORO-1,1'-BIPHENYL-4-YL)CARBONYL]-3-NITROBENZENESULFONAMIDE, Serum albumin | Authors: | Oltersdorf, T, Elmore, S.W, Shoemaker, A.R, Armstrong, R.C, Augeri, D.J, Belli, B.A, Bruncko, M, Deckwerth, T.L, Dinges, J, Hajduk, P.J, Joseph, M.K, Kitada, S, Korsmeyer, S.J, Kunzer, A.R, Letai, A, Li, C, Mitten, M.J, Nettesheim, D.G, Ng, S, Nimmer, P.M, O'Connor, J.M, Oleksijew, A, Petros, A.M, Reed, J.C, Shen, W, Tahir, S.K, Thompson, C.B, Tomaselli, K.J, Wang, B, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H. | Deposit date: | 2005-02-09 | Release date: | 2005-06-07 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | An inhibitor of Bcl-2 family proteins induces regression of solid tumours Nature, 435, 2005
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1YSN
| Solution structure of the anti-apoptotic protein Bcl-xL complexed with an acyl-sulfonamide-based ligand | Descriptor: | 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE, Apoptosis regulator Bcl-X | Authors: | Oltersdorf, T, Elmore, S.W, Shoemaker, A.R, Armstrong, R.C, Augeri, D.J, Belli, B.A, Bruncko, M, Deckwerth, T.L, Dinges, J, Hajduk, P.J, Joseph, M.K, Kitada, S, Korsmeyer, S.J, Kunzer, A.R, Letai, A, Li, C, Mitten, M.J, Nettesheim, D.G, Ng, S, Nimmer, P.M, O'Connor, J.M, Oleksijew, A, Petros, A.M, Reed, J.C, Shen, W, Tahir, S.K, Thompson, C.B, Tomaselli, K.J, Wang, B, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H. | Deposit date: | 2005-02-08 | Release date: | 2005-06-07 | Last modified: | 2023-11-29 | Method: | SOLUTION NMR | Cite: | An inhibitor of Bcl-2 family proteins induces regression of solid tumours Nature, 435, 2005
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1YSW
| Solution structure of the anti-apoptotic protein Bcl-2 complexed with an acyl-sulfonamide-based ligand | Descriptor: | 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE, Apoptosis regulator Bcl-2 | Authors: | Oltersdorf, T, Elmore, S.W, Shoemaker, A.R, Armstrong, R.C, Augeri, D.J, Belli, B.A, Bruncko, M, Deckwerth, T.L, Dinges, J, Hajduk, P.J, Joseph, M.K, Kitada, S, Korsmeyer, S.J, Kunzer, A.R, Letai, A, Li, C, Mitten, M.J, Nettesheim, D.G, Ng, S, Nimmer, P.M, O'Connor, J.M, Oleksijew, A, Petros, A.M, Reed, J.C, Shen, W, Tahir, S.K, Thompson, C.B, Tomaselli, K.J, Wang, B, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H. | Deposit date: | 2005-02-09 | Release date: | 2005-06-07 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | An inhibitor of Bcl-2 family proteins induces regression of solid tumours Nature, 435, 2005
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1YSG
| Solution Structure of the Anti-apoptotic Protein Bcl-xL in Complex with "SAR by NMR" Ligands | Descriptor: | 4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID, 5,6,7,8-TETRAHYDRONAPHTHALEN-1-OL, Apoptosis regulator Bcl-X | Authors: | Oltersdorf, T, Elmore, S.W, Shoemaker, A.R, Armstrong, R.C, Augeri, D.J, Belli, B.A, Bruncko, M, Deckwerth, T.L, Dinges, J, Hajduk, P.J, Joseph, M.K, Kitada, S, Korsmeyer, S.J, Kunzer, A.R, Letai, A, Li, C, Mitten, M.J, Nettesheim, D.G, Ng, S, Nimmer, P.M, O'Connor, J.M, Oleksijew, A, Petros, A.M, Reed, J.C, Shen, W, Tahir, S.K, Thompson, C.B, Tomaselli, K.J, Wang, B, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H. | Deposit date: | 2005-02-08 | Release date: | 2005-06-07 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | An inhibitor of Bcl-2 family proteins induces regression of solid tumours Nature, 435, 2005
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1KZZ
| DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3 | Descriptor: | TNF receptor associated factor 3, TRAF family member-associated NF-kappa-b activator | Authors: | Li, C, Ni, C.-Z, Havert, M.L, Cabezas, E, He, J, Kaiser, D, Reed, J.C, Satterthwait, A.C, Cheng, G, Ely, K.R. | Deposit date: | 2002-02-08 | Release date: | 2002-04-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Downstream regulator TANK binds to the CD40 recognition site on TRAF3. Structure, 10, 2002
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1YSI
| Solution structure of the anti-apoptotic protein Bcl-xL in complex with an acyl-sulfonamide-based ligand | Descriptor: | Apoptosis regulator Bcl-X, N-[(4'-FLUORO-1,1'-BIPHENYL-4-YL)CARBONYL]-3-NITRO-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE | Authors: | Oltersdorf, T, Elmore, S.W, Shoemaker, A.R, Armstrong, R.C, Augeri, D.J, Belli, B.A, Bruncko, M, Deckwerth, T.L, Dinges, J, Hajduk, P.J, Joseph, M.K, Kitada, S, Korsmeyer, S.J, Kunzer, A.R, Letai, A, Li, C, Mitten, M.J, Nettesheim, D.G, Ng, S, Nimmer, P.M, O'Connor, J.M, Oleksijew, A, Petros, A.M, Reed, J.C, Shen, W, Tahir, S.K, Thompson, C.B, Tomaselli, K.J, Wang, B, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H. | Deposit date: | 2005-02-08 | Release date: | 2005-06-07 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | An inhibitor of Bcl-2 family proteins induces regression of solid tumours Nature, 435, 2005
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1ZMS
| LMP1 Protein binds to TRAF3 as a structural CD40 | Descriptor: | Latent membrane protein 1, TNF receptor associated factor 3 | Authors: | Wu, S.D, Xie, P, Welsh, K, Li, C, Ni, C.-Z, Zhu, X, Reed, J.C, Satterthwait, A.C, Bishop, G.A, Ely, K.R. | Deposit date: | 2005-05-10 | Release date: | 2005-07-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | LMP1 protein from the Epstein Barr virus is a structural CD40 decoy in B lymphocytes fro binding to TRAF3 J.Biol.Chem., 39, 2005
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1L0A
| DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3 | Descriptor: | TNF receptor associated factor 3, TRAF family member-associated NF-kappa-b activator | Authors: | Li, C, Ni, C.-Z, Havert, M.L, Cabezas, E, He, J, Kaiser, D, Reed, J.C, Satterthwait, A.C, Cheng, G, Ely, K.R. | Deposit date: | 2002-02-08 | Release date: | 2002-04-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Downstream regulator TANK binds to the CD40 recognition site on TRAF3. Structure, 10, 2002
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1OTV
| PqqC, Pyrroloquinolinquinone Synthase C | Descriptor: | Coenzyme PQQ synthesis protein C | Authors: | Magnusson, O.T, Toyama, H, Saeki, M, Rojas, A, Reed, J.C, Adachi, O, Klinman, J.P, SChwarzenbacher, R. | Deposit date: | 2003-03-23 | Release date: | 2004-05-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Quinone Biogenesis: Structure and Mechanism of PqqC, the Final Catalyst in the Production of Pyrroloquinoline Quinone. Proc.Natl.Acad.Sci.USA, 101, 2004
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1OTW
| Crystal structure of PqqC in complex with PQQ and a putative H2O2 | Descriptor: | Coenzyme PQQ synthesis protein C, HYDROGEN PEROXIDE, PYRROLOQUINOLINE QUINONE | Authors: | Magnusson, O.T, Toyama, H, Saeki, M, Rojas, A, Reed, J.C, Liddington, R.C, Klinman, J.P, Schwarzenbacher, R. | Deposit date: | 2003-03-23 | Release date: | 2004-05-11 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Quinone biogenesis: Structure and mechanism of PqqC, the final catalyst in the production of pyrroloquinoline quinone. Proc.Natl.Acad.Sci.USA, 101, 2004
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1FLL
| MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3 | Descriptor: | B-CELL SURFACE ANTIGEN CD40, TNF RECEPTOR ASSOCIATED FACTOR 3 | Authors: | Ni, C.-Z, Welsh, K, Leo, E, Chiou, C.-K, Wu, H, Reed, J.C, Ely, K.R. | Deposit date: | 2000-08-14 | Release date: | 2000-10-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Molecular basis for CD40 signaling mediated by TRAF3. Proc.Natl.Acad.Sci.USA, 97, 2000
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1FLK
| MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3 | Descriptor: | TNF RECEPTOR ASSOCIATED FACTOR 3 | Authors: | Ni, C.-Z, Welsh, K, Leo, E, Chiou, C.-K, Wu, H, Reed, J.C, Ely, K.R. | Deposit date: | 2000-08-14 | Release date: | 2000-10-18 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Molecular basis for CD40 signaling mediated by TRAF3. Proc.Natl.Acad.Sci.USA, 97, 2000
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3H16
| Crystal structure of a bacteria TIR domain, PdTIR from Paracoccus denitrificans | Descriptor: | SULFATE ION, TIR protein | Authors: | Chan, S.L, Low, L.Y, Santelli, E, Pascual, J. | Deposit date: | 2009-04-11 | Release date: | 2009-06-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular Mimicry in Innate Immunity: CRYSTAL STRUCTURE OF A BACTERIAL TIR DOMAIN. J.Biol.Chem., 284, 2009
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1RCW
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4EWI
| Crystal structure of the NLRP4 Pyrin domain | Descriptor: | CHLORIDE ION, NACHT, LRR and PYD domains-containing protein 4, ... | Authors: | Eibl, C, Hessenberger, M, Puehringer, S, Page, R, Diederichs, K, Peti, W. | Deposit date: | 2012-04-27 | Release date: | 2012-09-05 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural and Functional Analysis of the NLRP4 Pyrin Domain. Biochemistry, 51, 2012
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2I39
| Crystal structure of Vaccinia virus N1L protein | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Protein N1 | Authors: | Aoyagi, M, Aleshin, A.E, Stec, B, Liddington, R.C. | Deposit date: | 2006-08-17 | Release date: | 2006-11-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein. Protein Sci., 16, 2007
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2GKW
| Key contacts promote recongnito of BAFF-R by TRAF3 | Descriptor: | TNF receptor-associated factor 3, Tumor necrosis factor receptor superfamily member 13C | Authors: | Ely, K.R. | Deposit date: | 2006-04-03 | Release date: | 2006-04-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Key molecular contacts promote recognition of the BAFF receptor by TNF receptor-associated factor 3: implications for intracellular signaling regulation. J.Immunol., 173, 2004
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