2FNB

NMR STRUCTURE OF THE FIBRONECTIN ED-B DOMAIN, NMR, 20 STRUCTURES

Summary for 2FNB

Entry DOI	10.2210/pdb2fnb/pdb
Descriptor	PROTEIN (FIBRONECTIN) (1 entity in total)
Functional Keywords	ed-b, fibronectin, typeiii domain, angiogenesis, protein binding
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix: P02751
Total number of polymer chains	1
Total formula weight	10148.23
Authors	Fattorusso, R.,Pellecchia, M.,Viti, F.,Neri, P.,Neri, D.,Wuthrich, K. (deposition date: 1998-12-16, release date: 1998-12-23, Last modification date: 2024-05-01)
Primary citation	Fattorusso, R.,Pellecchia, M.,Viti, F.,Neri, P.,Neri, D.,Wuthrich, K. NMR structure of the human oncofoetal fibronectin ED-B domain, a specific marker for angiogenesis. Structure Fold.Des., 7:381-390, 1999 Cited by PubMed Abstract: The process of angiogenesis (i.e. the formation of new blood vessels from pre-existing ones) is fundamental to physiological processes such as reproduction, development and repair, as well as to pathological conditions such as tumor progression, rheumathoid arthritis and ocular disorders. The oncofoetal ED-B domain, a specific marker of angiogenesis, consists of 91 amino acid residues that are inserted by alternative splicing into the fibronectin (FN) molecule. PubMed: 10196121 DOI: 10.1016/S0969-2126(99)80051-3 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation