2LWK
Solution structure of small molecule-influenza RNA complex
Summary for 2LWK
| Entry DOI | 10.2210/pdb2lwk/pdb |
| NMR Information | BMRB: 18633 |
| Descriptor | RNA (32-MER), 6,7-dimethoxy-2-(piperazin-1-yl)quinazolin-4-amine (2 entities in total) |
| Functional Keywords | double helix, rna, structural genomics, seattle structural genomics center for infectious disease, ssgcid |
| Total number of polymer chains | 1 |
| Total formula weight | 10547.43 |
| Authors | Lee, M.-K.,Varani, G.,Choi, B.-S.,Pellecchia, M.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2012-08-01, release date: 2012-08-29, Last modification date: 2024-05-15) |
| Primary citation | Lee, M.K.,Bottini, A.,Kim, M.,Bardaro, M.F.,Zhang, Z.,Pellecchia, M.,Choi, B.S.,Varani, G. A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication. Chem.Commun.(Camb.), 50:368-370, 2014 Cited by PubMed Abstract: Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA-DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits antiviral activity against influenza viruses. PubMed: 24247110DOI: 10.1039/c3cc46973e PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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