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1LUF
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BU of 1luf by Molmil
Crystal Structure of the MuSK Tyrosine Kinase: Insights into Receptor Autoregulation
分子名称: muscle-specific tyrosine kinase receptor musk
著者Till, J.H, Becerra, M, Watty, A, Lu, Y, Ma, Y, Neubert, T.A, Burden, S.J, Hubbard, S.R.
登録日2002-05-22
公開日2002-09-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation.
Structure, 10, 2002
5EG3
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BU of 5eg3 by Molmil
Crystal Structure of the Activated FGF Receptor 2 (FGFR2) Kinase Domain in complex with the cSH2 domain of Phospholipase C gamma (PLCgamma)
分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Fibroblast growth factor receptor 2, MAGNESIUM ION, ...
著者Huang, Z, Li, X, Mohammadi, M.
登録日2015-10-26
公開日2016-02-03
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.606 Å)
主引用文献Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase C gamma.
Mol.Cell, 61, 2016
3BU6
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BU of 3bu6 by Molmil
Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB phosphopeptide
分子名称: Insulin receptor substrate 2, insulin receptor subunit beta
著者Wu, J, Hubbard, S.R.
登録日2007-12-31
公開日2008-02-19
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2.
Nat.Struct.Mol.Biol., 15, 2008
6PNX
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BU of 6pnx by Molmil
Crystal Structure of an Asymmetric Dimer of FGF Receptor 3 Kinases Trapped in A-loop Tyrosine Transphosphorylation Reaction
分子名称: Fibroblast growth factor receptor 3, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
著者Mohammadi, M.
登録日2019-07-03
公開日2020-01-22
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.199 Å)
主引用文献Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation.
Nat.Chem.Biol., 16, 2020
3HBW
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BU of 3hbw by Molmil
Crystal Structure of Human Fibroblast Growth Factor Homologous Factor 2A (FHF2A), also referred to as Fibroblast Growth Factor 13A (FGF13A)
分子名称: Fibroblast growth factor 13
著者Mohammadi, M.
登録日2009-05-05
公開日2009-05-26
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels.
J.Biol.Chem., 284, 2009
8EM7
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BU of 8em7 by Molmil
Cryo-EM structure of LRP2 at pH 5.2
分子名称: 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Beenken, A, Cerutti, G, Fitzpatrick, A.W, Barasch, J, Shapiro, L.
登録日2022-09-27
公開日2023-02-08
最終更新日2023-03-08
実験手法ELECTRON MICROSCOPY (2.97 Å)
主引用文献Structures of LRP2 reveal a molecular machine for endocytosis.
Cell, 186, 2023
8EM4
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BU of 8em4 by Molmil
Cryo-EM structure of LRP2 at pH 7.5
分子名称: 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Beenken, A, Cerutti, G, Brasch, J, Fitzpatrick, A.W, Barasch, J, Shapiro, L.
登録日2022-09-26
公開日2023-02-08
最終更新日2023-03-08
実験手法ELECTRON MICROSCOPY (2.83 Å)
主引用文献Structures of LRP2 reveal a molecular machine for endocytosis.
Cell, 186, 2023
3BU3
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BU of 3bu3 by Molmil
Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB peptide
分子名称: Insulin receptor substrate 2, insulin receptor subunit beta
著者Wu, J, Hubbard, S.R.
登録日2007-12-31
公開日2008-02-19
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2.
Nat.Struct.Mol.Biol., 15, 2008
3BU5
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BU of 3bu5 by Molmil
Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB peptide and ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Insulin receptor substrate 2, MAGNESIUM ION, ...
著者Wu, J, Hubbard, S.R.
登録日2007-12-31
公開日2008-02-19
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2.
Nat.Struct.Mol.Biol., 15, 2008
3F1R
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BU of 3f1r by Molmil
Crystal structure of FGF20 dimer
分子名称: Fibroblast growth factor 20, SULFATE ION
著者Kalinina, J, Mohammadi, M.
登録日2008-10-28
公開日2009-07-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix
Mol.Cell.Biol., 29, 2009
3CLY
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BU of 3cly by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domains Trapped in Trans-Phosphorylation Reaction
分子名称: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
著者Chen, H, Mohammadi, M.
登録日2008-03-20
公開日2009-02-03
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A crystallographic snapshot of tyrosine trans-phosphorylation in action
Proc.Natl.Acad.Sci.USA, 105, 2008
4QQ5
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BU of 4qq5 by Molmil
Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex With FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations
分子名称: Fibroblast growth factor receptor 4, N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide
著者Huang, Z, Mohammadi, M.
登録日2014-06-26
公開日2014-10-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.203 Å)
主引用文献DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors.
Acs Chem.Biol., 10, 2015
4QQJ
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BU of 4qqj by Molmil
Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain Harboring the V550L Gate-Keeper Mutation
分子名称: Fibroblast growth factor receptor 4, SULFATE ION
著者Huang, Z, Mohammadi, M.
登録日2014-06-27
公開日2014-10-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.682 Å)
主引用文献DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors.
Acs Chem.Biol., 10, 2015
4QQT
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BU of 4qqt by Molmil
Crystal Structure of FGF Receptor (FGFR) 4 Tyrosine Kinase Domain
分子名称: Fibroblast growth factor receptor 4, SULFATE ION
著者Huang, Z, Mohammadi, M.
登録日2014-06-29
公開日2014-10-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.501 Å)
主引用文献DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors.
Acs Chem.Biol., 10, 2015
4QRC
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BU of 4qrc by Molmil
Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 4 in Complex with Ponatinib
分子名称: 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, Fibroblast growth factor receptor 4, SULFATE ION
著者Huang, Z, Mohammadi, M.
登録日2014-06-30
公開日2014-10-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.901 Å)
主引用文献DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors.
Acs Chem.Biol., 10, 2015
5UI0
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BU of 5ui0 by Molmil
Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring an E565A/K659M Double Gain-of-Function Mutation
分子名称: CITRATE ANION, Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
著者Mohammadi, M, Chen, H.
登録日2017-01-12
公開日2017-02-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
Elife, 6, 2017
5UHN
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BU of 5uhn by Molmil
Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 harboring a N549H/E565A Double Gain-of-Function Mutation
分子名称: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
著者Mohammadi, M, Chen, H.
登録日2017-01-11
公開日2017-02-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.909 Å)
主引用文献Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
Elife, 6, 2017
5UGX
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Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 2 Harboring a E565A/D650V double Gain-of-Function Mutation
分子名称: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
著者Mohammadi, M, Chen, H.
登録日2017-01-10
公開日2017-02-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.349 Å)
主引用文献Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
Elife, 6, 2017
5UGL
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BU of 5ugl by Molmil
Crystal Structure of FGF Receptor 2 Tyrosine Kinase Domain Harboring the D650V Activating Mutation
分子名称: Fibroblast growth factor receptor 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION
著者Mohammadi, M, Chen, H.
登録日2017-01-09
公開日2017-02-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.861 Å)
主引用文献Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
Elife, 6, 2017
4J99
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BU of 4j99 by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659T Mutation.
分子名称: Fibroblast growth factor receptor 2, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
著者Chen, H, Mohammadi, M.
登録日2013-02-15
公開日2013-08-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.8474 Å)
主引用文献Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4, 2013
4J95
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Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome in Space Group C2.
分子名称: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
著者Chen, H, Mohammadi, M.
登録日2013-02-15
公開日2013-08-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3767 Å)
主引用文献Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4, 2013
4J98
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BU of 4j98 by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Gain-of-Function K659Q Mutation.
分子名称: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
著者Huang, Z, Chen, H, Mohammadi, M.
登録日2013-02-15
公開日2013-08-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3067 Å)
主引用文献Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4, 2013
4J97
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BU of 4j97 by Molmil
Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659E Mutation Identified in Endometrial Cancer.
分子名称: Fibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION
著者Chen, H, Mohammadi, M.
登録日2013-02-15
公開日2013-08-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.5482 Å)
主引用文献Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4, 2013
4J96
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Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic Gain-of-Function K659M Mutation Identified in Cervical Cancer.
分子名称: CITRATE ANION, Fibroblast growth factor receptor 2, MAGNESIUM ION, ...
著者Chen, H, Mohammadi, M.
登録日2013-02-15
公開日2013-08-07
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2972 Å)
主引用文献Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4, 2013
4K33
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Crystal Structure of FGF Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, a Gain-of-Function Mutation Responsible for Thanatophoric Dysplasia Type II and Spermatocytic Seminoma
分子名称: Fibroblast growth factor receptor 3, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
著者Huang, Z, Chen, H, Mohammadi, M.
登録日2013-04-10
公開日2013-09-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3405 Å)
主引用文献Structural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 Mutation.
Structure, 21, 2013

 

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