4QQJ
Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain Harboring the V550L Gate-Keeper Mutation
Summary for 4QQJ
Entry DOI | 10.2210/pdb4qqj/pdb |
Related | 4QQ5 4QQC 4QQT |
Descriptor | Fibroblast growth factor receptor 4, SULFATE ION (3 entities in total) |
Functional Keywords | kinase domain fold, cell signaling, phosphotransferase, plasmamembrane, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Cytoplasm : P22455 |
Total number of polymer chains | 1 |
Total formula weight | 36333.66 |
Authors | Huang, Z.,Mohammadi, M. (deposition date: 2014-06-27, release date: 2014-10-29, Last modification date: 2023-09-20) |
Primary citation | Huang, Z.,Tan, L.,Wang, H.,Liu, Y.,Blais, S.,Deng, J.,Neubert, T.A.,Gray, N.S.,Li, X.,Mohammadi, M. DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors. Acs Chem.Biol., 10:299-309, 2015 Cited by PubMed: 25317566DOI: 10.1021/cb500674s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.682 Å) |
Structure validation
Download full validation report