4K33
Crystal Structure of FGF Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, a Gain-of-Function Mutation Responsible for Thanatophoric Dysplasia Type II and Spermatocytic Seminoma
Summary for 4K33
Entry DOI | 10.2210/pdb4k33/pdb |
Related | 2PSQ 2PVF 4J97 |
Descriptor | Fibroblast growth factor receptor 3, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | kinase domain fold consisting of n- and c-lobes, receptor tyrosine kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane ; Single-pass type I membrane protein . Isoform 3: Secreted. Isoform 4: Cell membrane ; Single-pass type I membrane protein : P22607 |
Total number of polymer chains | 1 |
Total formula weight | 37222.80 |
Authors | Huang, Z.,Chen, H.,Mohammadi, M. (deposition date: 2013-04-10, release date: 2013-09-11, Last modification date: 2023-09-20) |
Primary citation | Huang, Z.,Chen, H.,Blais, S.,Neubert, T.A.,Li, X.,Mohammadi, M. Structural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 Mutation. Structure, 21:1889-1896, 2013 Cited by PubMed: 23972473DOI: 10.1016/j.str.2013.07.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3405 Å) |
Structure validation
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