4K33

Crystal Structure of FGF Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, a Gain-of-Function Mutation Responsible for Thanatophoric Dysplasia Type II and Spermatocytic Seminoma

Summary for 4K33

Entry DOI	10.2210/pdb4k33/pdb
Related	2PSQ 2PVF 4J97
Descriptor	Fibroblast growth factor receptor 3, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	kinase domain fold consisting of n- and c-lobes, receptor tyrosine kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane ; Single-pass type I membrane protein . Isoform 3: Secreted. Isoform 4: Cell membrane ; Single-pass type I membrane protein : P22607
Total number of polymer chains	1
Total formula weight	37222.80
Authors	Huang, Z.,Chen, H.,Mohammadi, M. (deposition date: 2013-04-10, release date: 2013-09-11, Last modification date: 2023-09-20)
Primary citation	Huang, Z.,Chen, H.,Blais, S.,Neubert, T.A.,Li, X.,Mohammadi, M. Structural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 Mutation. Structure, 21:1889-1896, 2013 Cited by PubMed: 23972473 DOI: 10.1016/j.str.2013.07.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3405 Å)

Structure validation