4K33

Crystal Structure of FGF Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, a Gain-of-Function Mutation Responsible for Thanatophoric Dysplasia Type II and Spermatocytic Seminoma

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Fibroblast growth factor receptor 3	polymer	325	36669.0	1	UniProt (P22607) Pfam (PF07714)	Homo sapiens (human)	FGFR-3
2	B (A)	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	1	Chemie (ACP)
3	C, D (A)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	E (A)	water	water		18.0	124	Chemie (HOH)

Sequence modifications

A: 449 - 759 (UniProt: P22607)

PDB	External Database	Details
Met 435	-	expression tag
Gly 436	-	expression tag
Ser 437	-	expression tag
Ser 438	-	expression tag
His 439	-	expression tag
His 440	-	expression tag
His 441	-	expression tag
His 442	-	expression tag
His 443	-	expression tag
His 444	-	expression tag
Ser 445	-	expression tag
Gln 446	-	expression tag
Asp 447	-	expression tag
Pro 448	-	expression tag
Ala 482	Cys 482	engineered mutation
Ser 582	Cys 582	engineered mutation
Glu 650	Lys 650	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36669.0
Non-Polymers*	Number of molecules	3
	Total formula weight	553.8
All*	Total formula weight	37222.8

*Water molecules are not included.