4K33

Crystal Structure of FGF Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, a Gain-of-Function Mutation Responsible for Thanatophoric Dysplasia Type II and Spermatocytic Seminoma

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	BINDING SITE FOR RESIDUE ACP A 801

Chain	Residue
A	LEU478
A	VAL555
A	GLU556
A	ALA558
A	ASN562
A	ARG621
A	ASN622
A	LEU624
A	ASP635
A	ARG655
A	MG802
A	GLY479
A	MG803
A	HOH928
A	HOH933
A	HOH939
A	HOH940
A	HOH941
A	HOH942
A	HOH943
A	HOH944
A	HOH963
A	GLY481
A	HOH966
A	ALA482
A	PHE483
A	GLY484
A	VAL486
A	ALA506
A	LYS508

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 802

Chain	Residue
A	ASN622
A	ASP635
A	ACP801
A	HOH943
A	HOH944

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 803

Chain	Residue
A	ARG655
A	ACP801
A	HOH939
A	HOH940
A	HOH941
A	HOH963

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	31
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVmAeaigidkdraakpvt...VAVK

Chain	Residue	Details
A	LEU478-LYS508

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV

Chain	Residue	Details
A	CYS613-VAL625

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP617

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU478
A	LYS508

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000305|PubMed:8754806

Chain	Residue	Details
A	TYR647
A	TYR648

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:11294897

Chain	Residue	Details
A	TYR724

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