4K33

Crystal Structure of FGF Receptor 3 (FGFR3) Kinase Domain Harboring the K650E Mutation, a Gain-of-Function Mutation Responsible for Thanatophoric Dysplasia Type II and Spermatocytic Seminoma

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	BINDING SITE FOR RESIDUE ACP A 801

Chain	Residue
A	LEU478
A	VAL555
A	GLU556
A	ALA558
A	ASN562
A	ARG621
A	ASN622
A	LEU624
A	ASP635
A	ARG655
A	MG802
A	GLY479
A	MG803
A	HOH928
A	HOH933
A	HOH939
A	HOH940
A	HOH941
A	HOH942
A	HOH943
A	HOH944
A	HOH963
A	GLY481
A	HOH966
A	ALA482
A	PHE483
A	GLY484
A	VAL486
A	ALA506
A	LYS508

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 802

Chain	Residue
A	ASN622
A	ASP635
A	ACP801
A	HOH943
A	HOH944

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 803

Chain	Residue
A	ARG655
A	ACP801
A	HOH939
A	HOH940
A	HOH941
A	HOH963

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	31
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVmAeaigidkdraakpvt...VAVK

Chain	Residue	Details
A	LEU478-LYS508

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV

Chain	Residue	Details
A	CYS613-VAL625

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"8754806","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"11294897","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---