4QRC
Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 4 in Complex with Ponatinib
Summary for 4QRC
Entry DOI | 10.2210/pdb4qrc/pdb |
Related | 4QQ5 4QQC 4QQJ 4QQT |
Descriptor | Fibroblast growth factor receptor 4, SULFATE ION, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, ... (4 entities in total) |
Functional Keywords | kinase domain fold, cell signaling, phosphotransferase, plasmamembrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Cytoplasm : P22455 |
Total number of polymer chains | 1 |
Total formula weight | 37044.32 |
Authors | Huang, Z.,Mohammadi, M. (deposition date: 2014-06-30, release date: 2014-10-29, Last modification date: 2023-09-20) |
Primary citation | Huang, Z.,Tan, L.,Wang, H.,Liu, Y.,Blais, S.,Deng, J.,Neubert, T.A.,Gray, N.S.,Li, X.,Mohammadi, M. DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors. Acs Chem.Biol., 10:299-309, 2015 Cited by PubMed: 25317566DOI: 10.1021/cb500674s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.901 Å) |
Structure validation
Download full validation report