4QRC

Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 4 in Complex with Ponatinib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Fibroblast growth factor receptor 4	polymer	323	36127.5	1	UniProt (P22455) Pfam (PF07714)	Homo sapiens (human)	FGFR-4
2	B, D, E, F (A)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
3	C (A)	3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide	non-polymer		532.6	1	Chemie (0LI)
4	G (A)	water	water		18.0	95	Chemie (HOH)

Sequence modifications

A: 445 - 753 (UniProt: P22455)

PDB	External Database	Details
Met 431	-	expression tag
Gly 432	-	expression tag
Ser 433	-	expression tag
Ser 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
His 438	-	expression tag
His 439	-	expression tag
His 440	-	expression tag
Ser 441	-	expression tag
Gln 442	-	expression tag
Asp 443	-	expression tag
Pro 444	-	expression tag
Ala 477	Cys 477	engineered mutation
Glu 664	Arg 664	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36127.5
Non-Polymers*	Number of molecules	5
	Total formula weight	916.8
All*	Total formula weight	37044.3

*Water molecules are not included.