4QRC
Crystal Structure of the Tyrosine Kinase Domain of FGF Receptor 4 in Complex with Ponatinib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Fibroblast growth factor receptor 4 | polymer | 323 | 36127.5 | 1 | UniProt (P22455) Pfam (PF07714) In PDB | Homo sapiens (human) | FGFR-4 |
2 | A | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
3 | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | non-polymer | 532.6 | 1 | Chemie (0LI) | |||
4 | water | water | 18.0 | 95 | Chemie (HOH) |
Sequence modifications
A: 445 - 753 (UniProt: P22455)
PDB | External Database | Details |
---|---|---|
Met 431 | - | expression tag |
Gly 432 | - | expression tag |
Ser 433 | - | expression tag |
Ser 434 | - | expression tag |
His 435 | - | expression tag |
His 436 | - | expression tag |
His 437 | - | expression tag |
His 438 | - | expression tag |
His 439 | - | expression tag |
His 440 | - | expression tag |
Ser 441 | - | expression tag |
Gln 442 | - | expression tag |
Asp 443 | - | expression tag |
Pro 444 | - | expression tag |
Ala 477 | Cys 477 | engineered mutation |
Glu 664 | Arg 664 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36127.5 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 916.8 | |
All* | Total formula weight | 37044.3 |