4J95

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome in Space Group C2.

Summary for 4J95

Related2PSQ 2PVF 2PVY 4J96 4J97 4J98 4J99
DescriptorFibroblast growth factor receptor 2, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, SULFATE ION, ... (4 entities in total)
Functional Keywordskinase domain fold consisting of n- and c-lobes, receptor tyrosine kinase, atp binding, transferase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 14: Secreted. Isoform 19: Secreted P21802
Total number of polymer chains4
Total molecular weight151075.29
Authors
Chen, H.,Mohammadi, M. (deposition date: 2013-02-15, release date: 2013-08-07, Last modification date: 2016-12-28)
Primary citation
Chen, H.,Huang, Z.,Dutta, K.,Blais, S.,Neubert, T.A.,Li, X.,Cowburn, D.,Traaseth, N.J.,Mohammadi, M.
Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations.
Cell Rep, 4:376-384, 2013
PubMed: 23871672 (PDB entries with the same primary citation)
DOI: 10.1016/j.celrep.2013.06.025
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3767 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25551.0%1.6%7.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4j95.pdb1.gz [97.39 KB])
Coordinate files for Biological unit (4j95.pdb6.gz [191.09 KB])
Coordinate files for Biological unit (4j95.pdb3.gz [98.46 KB])
Coordinate files for Biological unit (4j95.pdb4.gz [96.65 KB])
Coordinate files for Biological unit (4j95.pdb2.gz [98.13 KB])
Coordinate files for Biological unit (4j95.pdb5.gz [191.42 KB])
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