4J95

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic K659N Mutation Responsible for an Unclassified Craniosynostosis Syndrome in Space Group C2.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Fibroblast growth factor receptor 2	polymer	324	37095.5	4	UniProt (P21802) Pfam (PF07714)	Homo sapiens (human)	FGFR-2, K-sam, KGFR, Keratinocyte growth factor receptor
2	E, H, J, N (A, B, C, D)	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	4	Chemie (ACP)
3	F, G, I, K, L... (A, B, C, D)	SULFATE ION	non-polymer		96.1	7	Chemie (SO4)
4	P, Q, R, S (A, B, C, D)	water	water		18.0	107	Chemie (HOH)

Sequence modifications

A, B, C, D: 458 - 768 (UniProt: P21802)

PDB	External Database	Details
Met 445	-	expression tag
Gly 446	-	expression tag
Ser 447	-	expression tag
Ser 448	-	expression tag
His 449	-	expression tag
His 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
Ser 455	-	expression tag
Gln 456	-	expression tag
Asp 457	-	expression tag
Ala 491	Cys 491	engineered mutation
Asn 659	Lys 659	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	148382.0
Non-Polymers*	Number of molecules	11
	Total formula weight	2693.3
All*	Total formula weight	151075.3

*Water molecules are not included.