8EM7

Cryo-EM structure of LRP2 at pH 5.2

Summary for 8EM7

Entry DOI	10.2210/pdb8em7/pdb
EMDB information	28233 28241 28242 28243 28250
Descriptor	Low-density lipoprotein receptor-related protein 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	lrp2, megalin, gp330, endocytosis, membrane protein
Biological source	Mus musculus (house mouse)
Total number of polymer chains	2
Total formula weight	1070856.04
Authors	Beenken, A.,Cerutti, G.,Fitzpatrick, A.W.,Barasch, J.,Shapiro, L. (deposition date: 2022-09-27, release date: 2023-02-08, Last modification date: 2023-03-08)
Primary citation	Beenken, A.,Cerutti, G.,Brasch, J.,Guo, Y.,Sheng, Z.,Erdjument-Bromage, H.,Aziz, Z.,Robbins-Juarez, S.Y.,Chavez, E.Y.,Ahlsen, G.,Katsamba, P.S.,Neubert, T.A.,Fitzpatrick, A.W.P.,Barasch, J.,Shapiro, L. Structures of LRP2 reveal a molecular machine for endocytosis. Cell, 186:821-, 2023 Cited by PubMed: 36750096 DOI: 10.1016/j.cell.2023.01.016 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.97 Å)

Structure validation