3BT7
 
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2BBQ
 | | STRUCTURAL BASIS FOR RECOGNITION OF POLYGLUTAMYL FOLATES BY THYMIDYLATE SYNTHASE | | 分子名称: | 10-PARPARGYL-5,8-DIDEAZAFOLATE-4-GLUTAMIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | | 著者 | Kamb, A, Finer-Moore, J, Stroud, R.M. | | 登録日 | 1992-09-16 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural basis for recognition of polyglutamyl folates by thymidylate synthase.
Biochemistry, 31, 1992
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8SBE
 | | Structure of the rat vesicular glutamate transporter 2 determined by single-particle Cryo-EM | | 分子名称: | Vesicular glutamate transporter 2 | | 著者 | Li, F, Finer-Moore, J, Eriksen, J, Cheng, Y, Edwards, R, Stroud, R. | | 登録日 | 2023-04-03 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Ion transport and regulation in a synaptic vesicle glutamate transporter.
Science, 368, 2020
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1TVU
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1TVV
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1TVW
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6VBG
 | | Lactose permease complex with thiodigalactoside and nanobody 9043 | | 分子名称: | Galactoside permease, beta-D-galactopyranose-(1-1)-1-thio-beta-D-galactopyranose, nanobody 9043, ... | | 著者 | Kumar, H, Stroud, R.M, Kaback, H.R, Finer-Moore, J, Smirnova, I, Kasho, V, Pardon, E, Steyart, J. | | 登録日 | 2019-12-18 | | 公開日 | 2020-11-25 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Diversity in kinetics correlated with structure in nano body-stabilized LacY.
Plos One, 15, 2020
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2TDM
 | | STRUCTURE OF THYMIDYLATE SYNTHASE | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | | 著者 | Finer-Moore, J, Stroud, R.M. | | 登録日 | 1997-03-28 | | 公開日 | 1997-08-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
J.Mol.Biol., 232, 1993
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1BP0
 | | THYMIDYLATE SYNTHASE R23I MUTANT | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, POTASSIUM ION, PROTEIN (THYMIDYLATE SYNTHASE) | | 著者 | Morse, R, Finer-Moore, J, Stroud, R.M. | | 登録日 | 1998-08-11 | | 公開日 | 2000-01-12 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
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1BO8
 | | THYMIDYLATE SYNTHASE R178T MUTANT | | 分子名称: | POTASSIUM ION, THYMIDYLATE SYNTHASE, URIDINE-5'-MONOPHOSPHATE | | 著者 | Morse, R, Finer-Moore, J, Stroud, R.M. | | 登録日 | 1998-08-10 | | 公開日 | 1998-08-19 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
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3SDM
 | | Structure of oligomeric kinase/RNase Ire1 in complex with an oligonucleotide | | 分子名称: | Serine/threonine-protein kinase/endoribonuclease IRE1 | | 著者 | Korennykh, A, Korostelev, A, Egea, P, Finer-Moore, J, Zhang, C, Stroud, R, Shokat, K, Walter, P. | | 登録日 | 2011-06-09 | | 公開日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (6.6 Å) | | 主引用文献 | Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1.
Bmc Biol., 9, 2011
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1BJG
 | | D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING | | 分子名称: | 5,10-METHYLENE-6-HYDROFOLIC ACID, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | | 著者 | Sage, C.R, Michelitsch, M.D, Finer-Moore, J, Stroud, R.M. | | 登録日 | 1998-06-25 | | 公開日 | 1998-11-04 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
Biochemistry, 37, 1998
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1BO7
 | | THYMIDYLATE SYNTHASE R179T MUTANT | | 分子名称: | THYMIDYLATE SYNTHASE, URIDINE-5'-MONOPHOSPHATE | | 著者 | Morse, R, Finer-Moore, J, Stroud, R.M. | | 登録日 | 1998-08-10 | | 公開日 | 1998-08-19 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
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4E28
 | | Structure of human thymidylate synthase in inactive conformation with a novel non-peptidic inhibitor | | 分子名称: | 2-{(2Z,5S)-4-hydroxy-2-[(2E)-(2-hydroxybenzylidene)hydrazinylidene]-2,5-dihydro-1,3-thiazol-5-yl}-N-[3-(trifluoromethyl)phenyl]acetamide, 2-{(5S)-2-[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]-4-oxo-4,5-dihydro-1,3-thiazol-5-yl}-N-[3-(trifluoromethyl)phenyl]acetamide, SULFATE ION, ... | | 著者 | Tochowicz, A, Finer-Moore, J, Stroud, R.M, Costi, M.P. | | 登録日 | 2012-03-07 | | 公開日 | 2012-11-14 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | | 主引用文献 | Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase.
J.Med.Chem., 55, 2012
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1THY
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8FVZ
 | | PiPT Y150A | | 分子名称: | CITRATE ANION, PHOSPHATE ION, Phosphate transporter | | 著者 | Gupta, M, Finer-Moore, J, Stroud, R.M. | | 登録日 | 2023-01-20 | | 公開日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Roles of PiPT residues in phosphate binding and transport tested by mutagenesis
To be published
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1JMG
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1JMF
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1JMH
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1JMI
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3NKA
 | | Crystal structure of AqpZ H174G,T183F | | 分子名称: | Aquaporin Z, GLYCEROL, octyl beta-D-glucopyranoside | | 著者 | Savage, D.F, O'Connell III, J.D, Finer-Moore, J, Stroud, R.M. | | 登録日 | 2010-06-18 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural context shapes the aquaporin selectivity filter.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3NKC
 | | Crystal structure of AqpZ F43W,H174G,T183F | | 分子名称: | Aquaporin Z, octyl beta-D-glucopyranoside | | 著者 | Savage, D.F, O'Connell III, J.D, Finer-Moore, J, Stroud, R.M. | | 登録日 | 2010-06-18 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structural context shapes the aquaporin selectivity filter.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3SDJ
 | | Structure of RNase-inactive point mutant of oligomeric kinase/RNase Ire1 | | 分子名称: | N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine, Serine/threonine-protein kinase/endoribonuclease IRE1 | | 著者 | Korennykh, A, Korostelev, A, Egea, P, Finer-Moore, J, Zhang, C, Stroud, R, Shokat, K, Walter, P. | | 登録日 | 2011-06-09 | | 公開日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | | 主引用文献 | Structural and functional basis for RNA cleavage by Ire1.
Bmc Biol., 9, 2011
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1DNA
 | | D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING | | 分子名称: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE | | 著者 | Sage, C.R, Michelitsch, M.D, Finer-Moore, J, Stroud, R.M. | | 登録日 | 1998-06-25 | | 公開日 | 1998-11-04 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
Biochemistry, 37, 1998
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1VZB
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