1DNA
D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING
Summary for 1DNA
| Entry DOI | 10.2210/pdb1dna/pdb |
| Descriptor | THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total) |
| Functional Keywords | transferase, active site mutant, reaction intermediate, methyltransferase |
| Biological source | Escherichia coli |
| Cellular location | Cytoplasm: P0A884 |
| Total number of polymer chains | 2 |
| Total formula weight | 62688.66 |
| Authors | Sage, C.R.,Michelitsch, M.D.,Finer-Moore, J.,Stroud, R.M. (deposition date: 1998-06-25, release date: 1998-11-04, Last modification date: 2021-11-03) |
| Primary citation | Sage, C.R.,Michelitsch, M.D.,Stout, T.J.,Biermann, D.,Nissen, R.,Finer-Moore, J.,Stroud, R.M. D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine. Biochemistry, 37:13893-13901, 1998 Cited by PubMed: 9753479DOI: 10.1021/bi9810510 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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