1TVW

CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN-229 MUTANTS OF THYMIDYLATE SYNTHASE

Summary for 1TVW

DescriptorTHYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ... (4 entities in total)
Functional Keywordstransferase, methyltransferase
Biological sourceLactobacillus casei
Cellular locationCytoplasm P00469
Total number of polymer chains1
Total molecular weight37389.08
Authors
Finer-Moore, J.,Stroud, R.M. (deposition date: 1997-09-17, release date: 1998-01-28, Last modification date: 2011-07-13)
Primary citation
Finer-Moore, J.S.,Liu, L.,Birdsall, D.L.,Brem, R.,Apfeld, J.,Santi, D.V.,Stroud, R.M.
Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase.
J.Mol.Biol., 276:113-129, 1998
PubMed: 9514716 (PDB entries with the same primary citation)
DOI: 10.1006/jmbi.1997.1495
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers18 2.9% 10.1% 0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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169117
PDB entries from 2020-09-23