1BP0

THYMIDYLATE SYNTHASE R23I MUTANT

Summary for 1BP0

Entry DOI	10.2210/pdb1bp0/pdb
Descriptor	PROTEIN (THYMIDYLATE SYNTHASE), POTASSIUM ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (4 entities in total)
Functional Keywords	methyltransferase, nucleotide biosynthesis, transferase
Biological source	Lactobacillus casei
Cellular location	Cytoplasm: P00469
Total number of polymer chains	1
Total formula weight	36933.70
Authors	Morse, R.,Finer-Moore, J.,Stroud, R.M. (deposition date: 1998-08-11, release date: 2000-01-12, Last modification date: 2023-08-09)
Primary citation	Morse, R.J.,Kawase, S.,Santi, D.V.,Finer-Moore, J.,Stroud, R.M. Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance". Biochemistry, 39:1011-1020, 2000 Cited by PubMed: 10653645 DOI: 10.1021/bi9918590 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation