1BJG

D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING

Summary for 1BJG

Entry DOI	10.2210/pdb1bjg/pdb
Descriptor	THYMIDYLATE SYNTHASE, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5,10-METHYLENE-6-HYDROFOLIC ACID, ... (4 entities in total)
Functional Keywords	transferase, active site mutant, reaction intermediate methyltransferase
Biological source	Escherichia coli
Cellular location	Cytoplasm: P0A884
Total number of polymer chains	1
Total formula weight	31340.27
Authors	Sage, C.R.,Michelitsch, M.D.,Finer-Moore, J.,Stroud, R.M. (deposition date: 1998-06-25, release date: 1998-11-04, Last modification date: 2024-04-03)
Primary citation	Sage, C.R.,Michelitsch, M.D.,Stout, T.J.,Biermann, D.,Nissen, R.,Finer-Moore, J.,Stroud, R.M. D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine. Biochemistry, 37:13893-13901, 1998 Cited by PubMed: 9753479 DOI: 10.1021/bi9810510 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation