9M1H
 
 | | Cryo-EM structure of PGE2-EP1-Gq complex | | 分子名称: | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Meng, X, Xu, Y, Xu, H.E. | | 登録日 | 2025-02-26 | | 公開日 | 2025-04-30 | | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | | 主引用文献 | Structural Insights into the Activation of Human Prostaglandin E2 Receptor EP1 Subtype by Prostaglandin E2
To Be Published
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8WZB
 | | RS head-neck monomer | | 分子名称: | DPY30 domain containing 2, DnaJ homolog subfamily B member 13, Nucleoside diphosphate kinase homolog 5, ... | | 著者 | Meng, X, Cong, Y. | | 登録日 | 2023-11-01 | | 公開日 | 2024-02-07 | | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | | 主引用文献 | Multi-scale structures of the mammalian radial spoke and divergence of axonemal complexes in ependymal cilia.
Nat Commun, 15, 2024
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8X2U
 | | Radial spoke head-neck dimer | | 分子名称: | DPY30 domain containing 2, DnaJ homolog subfamily B member 13, Nucleoside diphosphate kinase homolog 5, ... | | 著者 | Meng, X, Cong, Y. | | 登録日 | 2023-11-10 | | 公開日 | 2024-02-07 | | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | | 主引用文献 | Multi-scale structures of the mammalian radial spoke and divergence of axonemal complexes in ependymal cilia.
Nat Commun, 15, 2024
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5CZ3
 | | Crystal Structure of Myxoma Virus M64 | | 分子名称: | BETA-MERCAPTOETHANOL, M64R | | 著者 | Krumm, B.E, Meng, X, Li, Y, Xiang, Y, Deng, J. | | 登録日 | 2015-07-31 | | 公開日 | 2015-11-18 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis for antagonizing a host restriction factor by C7 family of poxvirus host-range proteins.
Proc.Natl.Acad.Sci.USA, 112, 2015
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5CYW
 | | Crystal Structure of Vaccinia Virus C7 | | 分子名称: | GLYCEROL, Interferon antagonist C7 | | 著者 | Krumm, B.E, Meng, X, Li, Y, Xiang, Y, Deng, J. | | 登録日 | 2015-07-30 | | 公開日 | 2015-11-18 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for antagonizing a host restriction factor by C7 family of poxvirus host-range proteins.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4W60
 | | The structure of Vaccina virus H7 protein displays A Novel Phosphoinositide binding fold required for membrane biogenesis | | 分子名称: | Late protein H7 | | 著者 | Kolli, S, Meng, X, Wu, X, Shengjuler, D, Cameron, C.E, Xiang, Y, Deng, J. | | 登録日 | 2014-08-19 | | 公開日 | 2014-12-31 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structure-function analysis of vaccinia virus h7 protein reveals a novel phosphoinositide binding fold essential for poxvirus replication.
J.Virol., 89, 2015
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3J34
 | | Structure of HIV-1 Capsid Protein by Cryo-EM | | 分子名称: | capsid protein | | 著者 | Zhao, G, Perilla, J.R, Yufenyuy, E, Meng, X, Chen, B, Ning, J, Ahn, J, Gronenborn, A.M, Schulten, K, Aiken, C, Zhang, P. | | 登録日 | 2013-02-23 | | 公開日 | 2013-05-29 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (8.6 Å) | | 主引用文献 | Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics.
Nature, 497, 2013
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6OMM
 | | Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi | | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhuang, Y, Liu, H, de Waal, P.W, Zhou, X.E, Wang, L, Meng, X, Zhao, G, Kang, Y, Melcher, K, Xu, H.E, Zhang, C. | | 登録日 | 2019-04-19 | | 公開日 | 2020-02-26 | | 最終更新日 | 2025-05-14 | | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | | 主引用文献 | Structure of formylpeptide receptor 2-Gicomplex reveals insights into ligand recognition and signaling.
Nat Commun, 11, 2020
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6PT0
 | | Cryo-EM structure of human cannabinoid receptor 2-Gi protein in complex with agonist WIN 55,212-2 | | 分子名称: | CHOLESTEROL, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Xu, T.H, Xing, C, Zhuang, Y, Feng, Z, Zhou, X.E, Chen, M, Wang, L, Meng, X, Xue, Y, Wang, J, Liu, H, McGuire, T, Zhao, G, Melcher, K, Zhang, C, Xu, H.E, Xie, X.Q. | | 登録日 | 2019-07-14 | | 公開日 | 2020-02-12 | | 最終更新日 | 2025-05-28 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM Structure of the Human Cannabinoid Receptor CB2-GiSignaling Complex.
Cell, 180, 2020
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6CMO
 | | Rhodopsin-Gi complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab Heavy chain, Fab light chain, ... | | 著者 | Kang, Y, Kuybeda, O, de Waal, P.W, Mukherjee, S, Van Eps, N, Dutka, P, Zhou, X.E, Bartesaghi, A, Erramilli, S, Morizumi, T, Gu, X, Yin, Y, Liu, P, Jiang, Y, Meng, X, Zhao, G, Melcher, K, Earnst, O.P, Kossiakoff, A.A, Subramaniam, S, Xu, H.E. | | 登録日 | 2018-03-05 | | 公開日 | 2018-06-20 | | 最終更新日 | 2025-05-28 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Nature, 558, 2018
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4XFU
 | | Structure of IL-18 SER Mutant V | | 分子名称: | Interleukin-18 | | 著者 | Krumm, B.E, Meng, X, Xiang, Y, Deng, J. | | 登録日 | 2014-12-29 | | 公開日 | 2015-06-10 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Crystallization of interleukin-18 for structure-based inhibitor design.
Acta Crystallogr.,Sect.F, 71, 2015
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4XFT
 | | Structure of IL-18 SER Mutant III | | 分子名称: | DIMETHYL SULFOXIDE, Interleukin-18 | | 著者 | Krumm, B.E, Meng, X, Xiang, Y, Deng, J. | | 登録日 | 2014-12-29 | | 公開日 | 2015-06-10 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystallization of interleukin-18 for structure-based inhibitor design.
Acta Crystallogr.,Sect.F, 71, 2015
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4XFS
 | | Structure of IL-18 SER Mutant I | | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, Interleukin-18 | | 著者 | Krumm, B.E, Meng, X, Xiang, Y, Deng, J. | | 登録日 | 2014-12-28 | | 公開日 | 2015-06-10 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Crystallization of interleukin-18 for structure-based inhibitor design.
Acta Crystallogr.,Sect.F, 71, 2015
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3J4F
 | | Structure of HIV-1 capsid protein by cryo-EM | | 分子名称: | capsid protein | | 著者 | Zhao, G, Perilla, J.R, Meng, X, Schulten, K, Zhang, P. | | 登録日 | 2013-07-11 | | 公開日 | 2013-07-24 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (8.6 Å) | | 主引用文献 | Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics.
Nature, 497, 2013
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7VUX
 | | Complex structure of PD1 and 609A-Fab | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Huang, H, Zhu, Z, Zhao, J, Jiang, L, Yang, H, Deng, L, Meng, X, Ding, J, Yang, S, Zhao, L, Xu, W, Wang, X. | | 登録日 | 2021-11-04 | | 公開日 | 2021-11-17 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | A strategy for the efficient construction of anti-PD1-based bispecific antibodies with desired IgG-like properties.
Mabs, 14, 2022
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4C13
 | | x-ray crystal structure of Staphylococcus aureus MurE with UDP-MurNAc- Ala-Glu-Lys | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, PHOSPHATE ION, ... | | 著者 | Ruane, K.M, Roper, D.I, Fulop, V, Barreteau, H, Boniface, A, Dementin, S, Blanot, D, Mengin-Lecreulx, D, Gobec, S, Dessen, A, Dowson, C.G, Lloyd, A.J. | | 登録日 | 2013-08-09 | | 公開日 | 2013-10-02 | | 最終更新日 | 2025-04-09 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy.
Nat.Chem.Biol., 2021
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4W5X
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4U6H
 | | Vaccinia L1/M12B9-Fab complex | | 分子名称: | Heavy chain of murine anti-vaccinia L1 IgG2a antibody M12B9, Light chain of murine anti-vaccinia L1 IgG2a antibody M12B9, Protein L1 | | 著者 | Matho, M.H, Schlossman, A, Zajonc, D.M. | | 登録日 | 2014-07-29 | | 公開日 | 2014-08-06 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Potent neutralization of vaccinia virus by divergent murine antibodies targeting a common site of vulnerability in l1 protein.
J.Virol., 88, 2014
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5JLJ
 | | Crystal Structure of KPT8602 in complex with CRM1-Ran-RanBP1 | | 分子名称: | (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, CHLORIDE ION, Exportin-1, ... | | 著者 | Fung, H.Y, Chook, Y.M. | | 登録日 | 2016-04-27 | | 公開日 | 2016-06-29 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.
Leukemia, 30, 2016
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7KX5
 | | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with noncovalent inhibitor Jun8-76-3A | | 分子名称: | 3C-like proteinase, GLYCEROL, N-([1,1'-biphenyl]-4-yl)-N-[(1R)-2-oxo-2-{[(1S)-1-phenylethyl]amino}-1-(pyridin-3-yl)ethyl]furan-2-carboxamide | | 著者 | Sacco, M, Wang, J, Chen, Y. | | 登録日 | 2020-12-03 | | 公開日 | 2020-12-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity.
J.Am.Chem.Soc., 143, 2021
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7RN0
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7RN1
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7FB8
 | | De Novo-Designed and Disulfide-Bridged Peptide Heterodimer - hd1 | | 分子名称: | ASP-ASP-LYS-ASP-CYS-ASP-GLU-TYR-CYS-LYS-LYS-THR-LYS-GLU-NH2, GLU-LE1-THR-GLY-HIS-ILE-GLU-GLY-PRO-THR-LE1-THR-LE1-HIS-CYS-LYS-NH2 | | 著者 | Yao, H, Yao, S, Zheng, Y, Moyer, A, Baker, D, Wu, C. | | 登録日 | 2021-07-08 | | 公開日 | 2022-05-18 | | 最終更新日 | 2023-11-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | De novo design and directed folding of disulfide-bridged peptide heterodimers.
Nat Commun, 13, 2022
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7FBA
 | | De Novo-Designed and Disulfide-Bridged Peptide Heterodimer - hd2 | | 分子名称: | ALA-LE1-CYS-GLU-CYS-GLY-PRO-THR-ARG-GLU-CYS-LYS-NH2, GLU-CYS-ARG-GLU-TYR-GLY-PRO-LE1-LYS-LE1-LE1-ALA-NH2 | | 著者 | Yao, H, Yao, S, Moyer, A, Zheng, Y, Baker, D, Wu, C. | | 登録日 | 2021-07-08 | | 公開日 | 2022-05-18 | | 最終更新日 | 2023-11-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | De novo design and directed folding of disulfide-bridged peptide heterodimers.
Nat Commun, 13, 2022
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7DTT
 | | Human Calcium-Sensing Receptor bound with calcium ions | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ling, S.L, Tian, C.L, Shi, P, Liu, S.L, Meng, X.Y, Sun, D.M, Liu, L, Shi, C.W. | | 登録日 | 2021-01-06 | | 公開日 | 2021-03-10 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca 2+ ions and L-tryptophan.
Cell Res., 31, 2021
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