8BBH
 
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6SF6
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4BKL
 | | Crystal structure of the arthritogenic antibody M2139 (Fab fragment) in complex with the triple-helical J1 peptide | | 分子名称: | J1 EPITOPE, M2139 FAB FRAGMENT HEAVY CHAIN, M2139 FAB FRAGMENT LIGHT CHAIN | | 著者 | Raposo, B, Dobritzsch, D, Ge, C, Ekman, D, Lindh, I, Foerster, M, Uysal, H, Schneider, G, Holmdahl, R. | | 登録日 | 2013-04-26 | | 公開日 | 2014-02-05 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Epitope-Specific Antibody Response is Controlled by Immunoglobulin Vh Polymorphisms.
J.Exp.Med., 211, 2014
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7O00
 | | Crystal structure of HLA-DR4 in complex with a HSP70 peptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chaperone protein DnaK, ... | | 著者 | Ge, C, Holmdahl, R. | | 登録日 | 2021-03-25 | | 公開日 | 2022-05-11 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor.
Ann Rheum Dis, 81, 2022
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7NZH
 | | Crystal structure of HLA-DR4 in complex with a citrullinated cilp peptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, ... | | 著者 | Ge, C, Holmdahl, R. | | 登録日 | 2021-03-24 | | 公開日 | 2022-05-11 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.831 Å) | | 主引用文献 | Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor.
Ann Rheum Dis, 81, 2022
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7NZF
 | | Crystal structure of HLA-DR4 in complex with a mutated human collagen type II peptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DR alpha chain, ... | | 著者 | Ge, C, Dobritzsch, D, Holmdahl, R. | | 登録日 | 2021-03-24 | | 公開日 | 2022-05-11 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor.
Ann Rheum Dis, 81, 2022
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2W60
 | | Anti citrullinated Collagen type 2 antibody acc4 | | 分子名称: | ANTI-CITRULLINATED COLLAGEN TYPE II FAB ACC4, NITRATE ION | | 著者 | Uysal, H, Bockermann, R, Nandakumar, K.S, Sehnert, B, Bajtner, E, Engstrom, A, Serre, G, Burkhardt, H, Thunnissen, M.M.G.M, Holmdahl, R. | | 登録日 | 2008-12-16 | | 公開日 | 2009-02-24 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.
J. Exp. Med., 206, 2009
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2W65
 | | Anti citrullinated Collagen type 2 antibody acc4 in complex with a citrullinated peptide | | 分子名称: | ANTI-CITRULLINATED COLLAGEN TYPE II FAB ACC4, COLLAGEN DERIVED PEPTIDE PCII-CIT1, SULFATE ION | | 著者 | Uysal, H, Bockermann, R, Nandakumar, K.S, Sehnert, B, Bajtner, E, Engstrom, A, Serre, G, Burkhardt, H, Thunnissen, M.M.G.M, Holmdahl, R. | | 登録日 | 2008-12-17 | | 公開日 | 2009-02-24 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis.
J. Exp. Med., 206, 2009
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5MUB
 | | ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (CG05) | | 分子名称: | ACC1 Fab fragment heavy chain, ACC1 Fab fragment light chain, triple-helical peptide containing the citrullinated C1 epitope of collagen type II,Collagen alpha-1(II) chain,triple-helical peptide containing the citrullinated C1 epitope of collagen type II | | 著者 | Dobritzsch, D, Holmdahl, R, Ge, C. | | 登録日 | 2017-01-13 | | 公開日 | 2017-07-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
JCI Insight, 2, 2017
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7NZE
 | | Crystal structure of HLA-DR4 in complex with a human collagen type II peptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Collagen alpha-1(II) chain, GLYCEROL, ... | | 著者 | Ge, C, Dobritzsch, D, Holmdahl, R. | | 登録日 | 2021-03-24 | | 公開日 | 2022-06-08 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor.
Ann Rheum Dis, 81, 2022
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5MU0
 | | ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03) | | 分子名称: | IA03 peptide containing the citrullinated C1 epitope of collagen type II,Collagen alpha-1(II) chain,IA03 peptide containing the citrullinated C1 epitope of collagen type II, heavy chain of ACC1 antibody Fab fragment, light chain of ACC1 antibody Fab fragment | | 著者 | Dobritzsch, D, Holmdahl, R, Ge, C. | | 登録日 | 2017-01-11 | | 公開日 | 2017-07-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
JCI Insight, 2, 2017
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5MV3
 | | ACC1 Fab fragment in complex with CII583-591 (CG10) | | 分子名称: | heavy chain of ACC1 Fab fragment, light chain of ACC1 Fab fragment, synthetic peptide containing the CII583-591 epitope of collagen type II,Collagen alpha-1(II) chain,synthetic peptide containing the CII583-591 epitope of collagen type II, | | 著者 | Dobritzsch, D, Holmdahl, R, Ge, C. | | 登録日 | 2017-01-15 | | 公開日 | 2017-07-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
JCI Insight, 2, 2017
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5MV4
 | | ACC1 Fab fragment in complex with citrullinated CII616-639 epitope of collagen type II (ptm23) | | 分子名称: | ACC1 antibody Fab fragment, heavy chain, light chain, ... | | 著者 | Dobritzsch, D, Holmdahl, R, Ge, C. | | 登録日 | 2017-01-15 | | 公開日 | 2017-07-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
JCI Insight, 2, 2017
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5MU2
 | | ACC1 Fab fragment in complex with CII583-591 (CG10) | | 分子名称: | ACC1 Fab fragment heavy chain, ACC1 Fab fragment light chain, synthetic peptide containing the CII583-591 epitope of collagen type II | | 著者 | Dobritzsch, D, Holmdahl, R, Ge, C. | | 登録日 | 2017-01-12 | | 公開日 | 2017-07-19 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
JCI Insight, 2, 2017
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6YXM
 | | Crystal structure of ACPA 1F2 in complex with CII-C-39-CIT | | 分子名称: | ACPA 1F2 Fab fragment - heavy chain, ACPA 1F2 Fab fragment - light chain, CII-C-39-CIT, ... | | 著者 | Ge, C, Holmdahl, R. | | 登録日 | 2020-05-03 | | 公開日 | 2021-05-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation.
Sci Adv, 8, 2022
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6YXK
 | | Crystal structure of ACPA 3F3 in complex with cit-vimentin 59-74 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACPA 3F3 Fab fragment - heavy chain, ACPA 3F3 Fab fragment - light chain, ... | | 著者 | Ge, C, Holmdahl, R. | | 登録日 | 2020-05-03 | | 公開日 | 2021-05-12 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation.
Sci Adv, 8, 2022
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6YXL
 | | Crystal structure of ACPA F3 | | 分子名称: | ACPA F3 Fab fragment - heavy chain, ACPA F3 Fab fragment - light chain, GLYCEROL, ... | | 著者 | Ge, C, Holmdahl, R. | | 登録日 | 2020-05-03 | | 公開日 | 2021-05-12 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation.
Sci Adv, 8, 2022
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2VL5
 | | Structure of anti-collagen type II FAb CIIC1 | | 分子名称: | CIIC1 ANTICOLLAGEN FAB | | 著者 | Uysal, H, Sehnert, B, Nandakumar, K.S, Boiers, U, Burkhardt, H, Holmdahl, R, Thunnissen, M.M. | | 登録日 | 2008-01-08 | | 公開日 | 2008-03-18 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The Crystal Structure of the Pathogenic Collagen Type II-Specific Mouse Monoclonal Antibody Ciic1 Fab: Structure to Function Analysis.
Mol.Immunol., 45, 2008
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2Y5T
 | | Crystal structure of the pathogenic autoantibody CIIC1 in complex with the triple-helical C1 peptide | | 分子名称: | C1, CHLORIDE ION, CIIC1 FAB FRAGMENT HEAVY CHAIN, ... | | 著者 | Dobritzsch, D, Lindh, I, Schneider, N, Uysal, H, Nandakumar, K.S, Burkhardt, H, Schneider, G, Holmdahl, R. | | 登録日 | 2011-01-17 | | 公開日 | 2011-12-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal Structure of an Arthritogenic Anticollagen Immune Complex.
Arthritis Rheum., 63, 2011
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5ODB
 | | Crystal structure of the RA-associated mAb D10 (chimeric Fab fragment) | | 分子名称: | D10 Fab fragment - heavy chain, D10 Fab fragment - light chain, GLYCEROL, ... | | 著者 | Dobritzsch, D, Ge, C, Holmdahl, R, Amara, K, Malmstrom, V. | | 登録日 | 2017-07-05 | | 公開日 | 2018-07-04 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Arthritis Rheumatol, 71, 2019
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5OCY
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5OD8
 | | Crystal structure of the RA-associated mAb B2 (Fab fragment) | | 分子名称: | B2 Fab fragment - Light chain, B2 Fab fragment - heavy chain | | 著者 | Dobritzsch, D, Ge, C, Holmdahl, R, Amara, K, Malmstrom, V. | | 登録日 | 2017-07-05 | | 公開日 | 2018-07-04 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Arthritis Rheumatol, 71, 2019
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5OCK
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5OD0
 | | Crystal structure of ACPA E4 | | 分子名称: | Fab fragment of ACPA E4 - Light chain, Fab fragment of ACPA E4 - heavy chain, GLYCEROL | | 著者 | Dobritzsch, D, Ge, C, Holmdahl, R. | | 登録日 | 2017-07-04 | | 公開日 | 2018-07-04 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Arthritis Rheumatol, 71, 2019
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5OCX
 | | Crystal structure of ACPA E4 in complex with CII-C-13-CIT | | 分子名称: | 1,2-ETHANEDIOL, CII-C-13-CIT, Fab fragment anti-citrullinated protein antibody E4 - light chain, ... | | 著者 | Dobritzsch, D, Ge, C, Holmdahl, R. | | 登録日 | 2017-07-04 | | 公開日 | 2018-07-04 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Arthritis Rheumatol, 71, 2019
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