2Y5T

Crystal structure of the pathogenic autoantibody CIIC1 in complex with the triple-helical C1 peptide

Summary for 2Y5T

Entry DOI	10.2210/pdb2y5t/pdb
Descriptor	CIIC1 FAB FRAGMENT HEAVY CHAIN, CIIC1 FAB FRAGMENT LIGHT CHAIN, C1, ... (7 entities in total)
Functional Keywords	immune system, antibody, rheumatoid arthritis, arthritogenic
Biological source	MUS MUSCULUS (HOUSE MOUSE) More
Total number of polymer chains	5
Total formula weight	58871.68
Authors	Dobritzsch, D.,Lindh, I.,Schneider, N.,Uysal, H.,Nandakumar, K.S.,Burkhardt, H.,Schneider, G.,Holmdahl, R. (deposition date: 2011-01-17, release date: 2011-12-14, Last modification date: 2023-12-20)
Primary citation	Dobritzsch, D.,Lindh, I.,Uysal, H.,Nandakumar, K.S.,Burkhardt, H.,Schneider, G.,Holmdahl, R. Crystal Structure of an Arthritogenic Anticollagen Immune Complex. Arthritis Rheum., 63:3740-, 2011 Cited by PubMed: 22127694 DOI: 10.1002/ART.30611 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation