5MUB

ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (CG05)

Summary for 5MUB

Entry DOI	10.2210/pdb5mub/pdb
Descriptor	ACC1 Fab fragment heavy chain, ACC1 Fab fragment light chain, triple-helical peptide containing the citrullinated C1 epitope of collagen type II,Collagen alpha-1(II) chain,triple-helical peptide containing the citrullinated C1 epitope of collagen type II, ... (4 entities in total)
Functional Keywords	anti-citrullinated protein antibody (acpa), fab fragment, collagen type ii, citrullinated triple-helical c1 epitope, immune system
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	24
Total formula weight	401152.84
Authors	Dobritzsch, D.,Holmdahl, R.,Ge, C. (deposition date: 2017-01-13, release date: 2017-07-19, Last modification date: 2024-01-17)
Primary citation	Ge, C.,Tong, D.,Liang, B.,Lonnblom, E.,Schneider, N.,Hagert, C.,Viljanen, J.,Ayoglu, B.,Stawikowska, R.,Nilsson, P.,Fields, G.B.,Skogh, T.,Kastbom, A.,Kihlberg, J.,Burkhardt, H.,Dobritzsch, D.,Holmdahl, R. Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage. JCI Insight, 2:-, 2017 Cited by PubMed: 28679953 DOI: 10.1172/jci.insight.93688 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation