6SF6
Crystal structure of the mAb 15A in complex with COMP-epitope P6
Summary for 6SF6
Entry DOI | 10.2210/pdb6sf6/pdb |
Descriptor | COMP-reactive monoclonal antibody 15A Fab fragment, heavy chain, COMP-reactive monoclonal antibody 15A Fab fragment, light chain, P6 epitope of cartilage oligomeric matrix protein (COMP), ... (6 entities in total) |
Functional Keywords | cartilage oligomeric matrix protein, autoantibody, arthrogenicity, acpa, immune system |
Biological source | Mus musculus (House mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 104237.92 |
Authors | Dobritzsch, D.,Ge, C.,Holmdahl, R. (deposition date: 2019-08-01, release date: 2020-06-24, Last modification date: 2024-01-24) |
Primary citation | Ge, C.,Tong, D.,Loennblom, E.,Bibo, L.,Hagert, C.,Kastbom, A.,Gjertsson, I.,Dobritzsch, D.,Holmdahl, R. Antibodies to cartilage oligomeric matrix protein in vivo are pathogenic and clinically relevant in rheumatoid arthritis To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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