6YXK

Crystal structure of ACPA 3F3 in complex with cit-vimentin 59-74

Summary for 6YXK

Entry DOI	10.2210/pdb6yxk/pdb
Descriptor	ACPA 3F3 Fab fragment - heavy chain, ACPA 3F3 Fab fragment - light chain, Citrullinated Vimentin (59-74), ... (5 entities in total)
Functional Keywords	anti-citrullinated protein antibody fab fragment, citrullinated vimentin, immune system
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	50268.93
Authors	Ge, C.,Holmdahl, R. (deposition date: 2020-05-03, release date: 2021-05-12, Last modification date: 2024-01-24)
Primary citation	Kissel, T.,Ge, C.,Hafkenscheid, L.,Kwekkeboom, J.C.,Slot, L.M.,Cavallari, M.,He, Y.,van Schie, K.A.,Vergroesen, R.D.,Kampstra, A.S.B.,Reijm, S.,Stoeken-Rijsbergen, G.,Koeleman, C.,Voortman, L.M.,Heitman, L.H.,Xu, B.,Pruijn, G.J.M.,Wuhrer, M.,Rispens, T.,Huizinga, T.W.J.,Scherer, H.U.,Reth, M.,Holmdahl, R.,Toes, R.E.M. Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation. Sci Adv, 8:eabm1759-eabm1759, 2022 Cited by PubMed: 35138894 DOI: 10.1126/sciadv.abm1759 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation