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1ZZP
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BU of 1zzp by Molmil
Solution structure of the F-actin binding domain of Bcr-Abl/c-Abl
分子名称: Proto-oncogene tyrosine-protein kinase ABL1
著者Hantschel, O, Wiesner, S, Guttler, T, Mackereth, C.D, Rix, L.L.R, Mikes, Z, Dehne, J, Gorlich, D, Sattler, M, Superti-Furga, G.
登録日2005-06-14
公開日2005-08-30
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structural Basis for the Cytoskeletal Association of Bcr-Abl/c-Abl.
Mol.Cell, 19, 2005
6SM5
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BU of 6sm5 by Molmil
MbC/SHP1-C-SH2 complex
分子名称: MbC (monobody targeting SHP1-C-SH2), Tyrosine-protein phosphatase non-receptor type 6
著者Mann, G, Hantschel, O.
登録日2019-08-21
公開日2021-01-13
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献MbC/SHP1-C-SH2 complex
To Be Published
1OPL
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BU of 1opl by Molmil
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
分子名称: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, MYRISTIC ACID, proto-oncogene tyrosine-protein kinase
著者Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J.
登録日2003-03-06
公開日2003-04-08
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (3.42 Å)
主引用文献Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
1OPK
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BU of 1opk by Molmil
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
分子名称: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ...
著者Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J.
登録日2003-03-06
公開日2003-04-08
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
1OPJ
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BU of 1opj by Molmil
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
分子名称: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, CHLORIDE ION, MYRISTIC ACID, ...
著者Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J.
登録日2003-03-06
公開日2003-04-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
6TLC
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BU of 6tlc by Molmil
Unphosphorylated human STAT3 in complex with MS3-6 monobody
分子名称: Monobody, Signal transducer and activator of transcription 3
著者La Sala, G, Lau, K, Reynaud, A, Pojer, F, Hantschel, O.
登録日2019-12-02
公開日2020-07-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains.
Nat Commun, 11, 2020
3FW1
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BU of 3fw1 by Molmil
Quinone Reductase 2
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Winger, J.A, Hantschel, O, Superti-Furga, G, Kuriyan, J.
登録日2009-01-16
公開日2009-03-10
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2).
Bmc Struct.Biol., 9, 2009
6HTF
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BU of 6htf by Molmil
Crystal structure of human Btk SH2 domain bound to rF10 repebody
分子名称: Tyrosine-protein kinase BTK, rF10 repebody
著者Duarte, D.P, Pojer, F, Hantschel, O.
登録日2018-10-04
公開日2020-05-20
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.102 Å)
主引用文献Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms.
Nat Commun, 11, 2020
2FO0
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BU of 2fo0 by Molmil
Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase
分子名称: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ...
著者Nagar, B, Hantschel, O, Seeliger, M, Davies, J.M, Weis, W.I, Superti-Furga, G, Kuriyan, J.
登録日2006-01-12
公開日2006-03-21
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
Mol.Cell, 21, 2006
6O02
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BU of 6o02 by Molmil
Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL
分子名称: E3 ubiquitin-protein ligase CBL, Monobody (MC3)
著者Kukenshoner, T, Pojer, F, Hantschel, O.
登録日2019-02-15
公開日2020-08-19
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.953 Å)
主引用文献Monobody (MC3) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL
To Be Published
6O03
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BU of 6o03 by Molmil
Monobody (MC17) bound to tyrosine kinase binding domain of E3 ubiquitin ligase CBL
分子名称: E3 ubiquitin-protein ligase CBL, Monobody (MC17)
著者Kukenshoner, T, Pojer, F, Hantschel, O.
登録日2019-02-15
公開日2020-08-19
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Monobody (MC17) bound to tyrosine kinase binding domain of E3 ligase CBL
To Be Published
5MTN
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BU of 5mtn by Molmil
Monobody Mb(Lck_1) bound to Lck-Sh2
分子名称: Monobody Mb(Lck_1), SULFATE ION, Tyrosine-protein kinase Lck
著者Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O.
登録日2017-01-10
公開日2017-04-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
5MTJ
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BU of 5mtj by Molmil
Yes1-SH2 in complex with monobody Mb(Yes_1)
分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Monobody Mb(Yes_1), SULFATE ION, ...
著者Sha, F, Kukenshoner, T, Koide, S, Hantschel, O.
登録日2017-01-09
公開日2017-04-05
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.949 Å)
主引用文献Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
5MTM
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BU of 5mtm by Molmil
Monobody Mb(Lck_3) bound to Lck-SH2 domain
分子名称: Monobody Mb(Lck_3), Tyrosine-protein kinase Lck, ZINC ION
著者Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O.
登録日2017-01-10
公開日2017-04-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.405 Å)
主引用文献Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
J. Mol. Biol., 429, 2017
6ZZD
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BU of 6zzd by Molmil
MB_CRS6-13 bound to CrSAS-6_N
分子名称: Centriole protein, MB_CRS6-13
著者Hatzopoulos, G.N, Kukenshoner, T, Banterle, N, Favez, T, Fluckiger, I, Hantschel, O, Gonczy, P.
登録日2020-08-04
公開日2021-07-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly.
Nat Commun, 12, 2021
6ZZG
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BU of 6zzg by Molmil
MB_CRS6-1 bound to CrSAS-6_N
分子名称: ACETATE ION, Centriole protein, MB_CRS6-15
著者Hatzopoulos, G.N, Kukenshoner, T, Banterle, N, Favez, T, Fluckiger, I, Hantschel, O, Gonczy, P.
登録日2020-08-04
公開日2021-07-07
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.93 Å)
主引用文献Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly.
Nat Commun, 12, 2021
6ZZ8
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BU of 6zz8 by Molmil
MB_CRS6-15 bound to CrSAS-6_6HR
分子名称: Centriole protein, Protein B
著者Hatzopoulos, G.N, Kukenshoner, T, Banterle, N, Favez, T, Fluckiger, I, Hantschel, O, Gonczy, P.
登録日2020-08-04
公開日2021-07-07
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.73 Å)
主引用文献Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly.
Nat Commun, 12, 2021
6ZZC
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BU of 6zzc by Molmil
MB_CRS6-1 bound to CrSAS-6_6HR
分子名称: Centriole protein, DODECAETHYLENE GLYCOL, MB_CrS6-1
著者Hatzopoulos, G.N, Kukenshoner, T, Banterle, N, Favez, T, Fluckiger, I, Hantschel, O, Gonczy, P.
登録日2020-08-04
公開日2021-07-07
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.93 Å)
主引用文献Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly.
Nat Commun, 12, 2021
5N6R
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BU of 5n6r by Molmil
Solution structure of the Dbl-homology domain of Bcr-Abl
分子名称: Breakpoint cluster region protein
著者Reckel, S, Lohr, F, Buchner, L, Guntert, P, Dotsch, V, Hantschel, O.
登録日2017-02-16
公開日2017-12-27
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.
Nat Commun, 8, 2017
5N7E
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BU of 5n7e by Molmil
Crystal structure of the Dbl-homology domain of Bcr-Abl in complex with monobody Mb(Bcr-DH_4).
分子名称: Breakpoint cluster region protein, Mb(Bcr-DH_4)
著者Reckel, S, Reynaud, A, Pojer, F, Hantschel, O.
登録日2017-02-20
公開日2017-12-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.647 Å)
主引用文献Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.
Nat Commun, 8, 2017
5OC7
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BU of 5oc7 by Molmil
Crystal structure of the pleckstrin-homology domain of Bcr-Abl in complex with monobody Mb(Bcr-PH_4).
分子名称: Breakpoint cluster region protein,pleckstrin-homology domain of Bcr-Abl, D-MYO-INOSITOL-4,5-BISPHOSPHATE, GLYCEROL, ...
著者Reckel, S, Reynaud, A, Pojer, F, Hantschel, O.
登録日2017-06-29
公開日2017-12-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.652 Å)
主引用文献Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.
Nat Commun, 8, 2017
4XEY
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BU of 4xey by Molmil
Crystal structure of an SH2-kinase domain construct of c-Abl tyrosine kinase
分子名称: N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Tyrosine-protein kinase ABL1
著者Lorenz, S, Deng, P, Kuriyan, J.
登録日2014-12-25
公開日2015-04-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.891 Å)
主引用文献Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity.
Biochem.J., 468, 2015
3K2M
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BU of 3k2m by Molmil
Crystal Structure of Monobody HA4/Abl1 SH2 Domain Complex
分子名称: Monobody HA4, PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase ABL1
著者Wojcik, J.B, Duguid, E.
登録日2009-09-30
公開日2010-03-31
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain.
Nat.Struct.Mol.Biol., 17, 2010
3T04
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BU of 3t04 by Molmil
Crystal structure of monobody 7c12/abl1 sh2 domain complex
分子名称: GLYCEROL, MONOBODY 7C12, SULFATE ION, ...
著者Wojcik, J.B, Wyrzucki, A.M, Koide, S.
登録日2011-07-19
公開日2011-11-23
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis.
Cell(Cambridge,Mass.), 147, 2011
3BKB
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BU of 3bkb by Molmil
Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES)
分子名称: 1,2-ETHANEDIOL, Proto-oncogene tyrosine-protein kinase Fes/Fps, STAUROSPORINE, ...
著者Filippakopoulos, P, Salah, E, Fedorov, O, Cooper, C, Ugochukwu, E, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Knapp, S, Structural Genomics Consortium (SGC)
登録日2007-12-06
公開日2007-12-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
Cell(Cambridge,Mass.), 134, 2008

 

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