3FW1

Quinone Reductase 2

Summary for 3FW1

Entry DOI	10.2210/pdb3fw1/pdb
Descriptor	Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (6 entities in total)
Functional Keywords	oxidoreductase, flavoprotein, metalloprotein, imatinib complex, cytoplasm, fad, metal-binding, phosphoprotein, polymorphism, zinc
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P16083
Total number of polymer chains	1
Total formula weight	27689.58
Authors	Winger, J.A.,Hantschel, O.,Superti-Furga, G.,Kuriyan, J. (deposition date: 2009-01-16, release date: 2009-03-10, Last modification date: 2023-09-06)
Primary citation	Winger, J.A.,Hantschel, O.,Superti-Furga, G.,Kuriyan, J. The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2). Bmc Struct.Biol., 9:7-7, 2009 Cited by PubMed Abstract: Imatinib represents the first in a class of drugs targeted against chronic myelogenous leukemia to enter the clinic, showing excellent efficacy and specificity for Abl, Kit, and PDGFR kinases. Recent screens carried out to find off-target proteins that bind to imatinib identified the oxidoreductase NQO2, a flavoprotein that is phosphorylated in a chronic myelogenous leukemia cell line. PubMed: 19236722 DOI: 10.1186/1472-6807-9-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation