5OC7

Crystal structure of the pleckstrin-homology domain of Bcr-Abl in complex with monobody Mb(Bcr-PH_4).

Summary for 5OC7

Entry DOI	10.2210/pdb5oc7/pdb
Descriptor	Breakpoint cluster region protein,pleckstrin-homology domain of Bcr-Abl, monobody Mb(Bcr-PH_4), GLYCEROL, ... (5 entities in total)
Functional Keywords	pleckstrin-homology, monobody, bcr-abl, phosphoinositide-binding, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	51536.44
Authors	Reckel, S.,Reynaud, A.,Pojer, F.,Hantschel, O. (deposition date: 2017-06-29, release date: 2017-12-27, Last modification date: 2024-01-17)
Primary citation	Reckel, S.,Gehin, C.,Tardivon, D.,Georgeon, S.,Kukenshoner, T.,Lohr, F.,Koide, A.,Buchner, L.,Panjkovich, A.,Reynaud, A.,Pinho, S.,Gerig, B.,Svergun, D.,Pojer, F.,Guntert, P.,Dotsch, V.,Koide, S.,Gavin, A.C.,Hantschel, O. Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase. Nat Commun, 8:2101-2101, 2017 Cited by PubMed: 29235475 DOI: 10.1038/s41467-017-02313-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.652 Å)

Structure validation