5OC7
Crystal structure of the pleckstrin-homology domain of Bcr-Abl in complex with monobody Mb(Bcr-PH_4).
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (D, A) | Breakpoint cluster region protein,pleckstrin-homology domain of Bcr-Abl | polymer | 133 | 15643.1 | 2 | UniProt (P11274) Pfam (PF19057) | Homo sapiens (Human) | Renal carcinoma antigen NY-REN-26 |
| 2 | C, D (C, B) | monobody Mb(Bcr-PH_4) | polymer | 92 | 9632.8 | 2 | synthetic construct | ||
| 3 | E, G, H, I, J... (D, A, C, B) | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
| 4 | F (D) | D-MYO-INOSITOL-4,5-BISPHOSPHATE | non-polymer | 340.1 | 1 | Chemie (IP2) | |||
| 5 | M, N, O, P (D, A, C, B) | water | water | 18.0 | 253 | Chemie (HOH) |
Sequence modifications
D, A: 704 - 769 (UniProt: P11274)
D, A: 830 - 893 (PDB: 5OC7)
| PDB | External Database | Details |
|---|---|---|
| Gly 701 | - | expression tag |
| Ala 702 | - | expression tag |
| Met 703 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 50551.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 984.8 | |
| All* | Total formula weight | 51536.4 |
