6X45
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8D51
| Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing beta-3-homotryptophan | 分子名称: | 1,2-ETHANEDIOL, PTHrP[1-36], Parathyroid hormone/parathyroid hormone-related peptide receptor, ... | 著者 | Yu, Z, Kreitler, D.F, Gellman, S.H. | 登録日 | 2022-06-03 | 公開日 | 2023-06-14 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Harnessing Aromatic-Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification. Angew.Chem.Int.Ed.Engl., 62, 2023
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8D52
| Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing (2-naphthyl)-beta-3-homoalanine | 分子名称: | 1,2-ETHANEDIOL, PTHrP[1-36], Parathyroid hormone/parathyroid hormone-related peptide receptor, ... | 著者 | Yu, Z, Kreitler, D.F, Gellman, S.H. | 登録日 | 2022-06-03 | 公開日 | 2023-06-14 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Harnessing Aromatic-Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification. Angew.Chem.Int.Ed.Engl., 62, 2023
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3C3F
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3C3G
| alpha/beta-Peptide helix bundles: The GCN4-pLI side chain sequence on an (alpha-alpha-beta) backbone | 分子名称: | GLYCEROL, alpha/beta peptide with the GCN4-pLI side chain sequence on an (alpha-alpha-beta) backbone | 著者 | Horne, W.S, Price, J.L, Gellman, S.H. | 登録日 | 2008-01-28 | 公開日 | 2008-06-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly. Proc.Natl.Acad.Sci.Usa, 105, 2008
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4WPB
| Vascular endothelial growth factor in complex with alpha/beta-VEGF-1 | 分子名称: | Vascular endothelial growth factor A, alpha/beta-VEGF-1 | 著者 | Kreitler, D.F, Checco, J.W, Gellman, S.H, Forest, K.T. | 登録日 | 2014-10-17 | 公開日 | 2015-04-15 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | 主引用文献 | Targeting diverse protein-protein interaction interfaces with alpha / beta-peptides derived from the Z-domain scaffold. Proc.Natl.Acad.Sci.USA, 112, 2015
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3TJW
| Crystal Structure of Quasiracemic Villin Headpiece Subdomain Containing (F5Phe10) Substitution | 分子名称: | D-Villin-1, L-Villin-1, SULFATE ION | 著者 | Mortenson, D.E, Satyshur, K.A, Gellman, S.H, Forest, K.T. | 登録日 | 2011-08-25 | 公開日 | 2012-01-25 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Quasiracemic crystallization as a tool to assess the accommodation of noncanonical residues in nativelike protein conformations. J.Am.Chem.Soc., 134, 2012
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3TRV
| Crystal structure of quasiracemic villin headpiece subdomain containing (F5Phe17) substitution | 分子名称: | D-Villin-1, ISOPROPYL ALCOHOL, L-Villin-1, ... | 著者 | Mortenson, D.E, Satyshur, K.A, Gellman, S.H, Forest, K.T. | 登録日 | 2011-09-11 | 公開日 | 2012-01-25 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Quasiracemic crystallization as a tool to assess the accommodation of noncanonical residues in nativelike protein conformations. J.Am.Chem.Soc., 134, 2012
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3TRY
| Crystal structure of racemic villin headpiece subdomain in space group I-4c2 | 分子名称: | D-Villin-1, SULFATE ION | 著者 | Mortenson, D.E, Satyshur, K.A, Gellman, S.H, Forest, K.T. | 登録日 | 2011-09-11 | 公開日 | 2012-01-25 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Quasiracemic crystallization as a tool to assess the accommodation of noncanonical residues in nativelike protein conformations. J.Am.Chem.Soc., 134, 2012
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2JM0
| Solution structure of chicken villin headpiece subdomain containing a fluorinated side chain in the core | 分子名称: | Villin-1 | 著者 | Cornilescu, C.C, Cornilescu, G, Hadley, E.B, Gellman, S.H, Markley, J.L. | 登録日 | 2006-09-06 | 公開日 | 2006-10-17 | 最終更新日 | 2023-12-20 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of a small protein containing a fluorinated side chain in the core. Protein Sci., 16, 2007
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7S1M
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7TA3
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7TA6
| Trimer-to-Monomer Disruption of Tumor Necrosis Factor-alpha (TNF-alpha) by unnatural alpha/beta-peptide-1 | 分子名称: | 1,2-ETHANEDIOL, AMINO GROUP, Alpha/Beta-peptide-1, ... | 著者 | Niu, J, Bingman, C.A, Gellman, S.H. | 登録日 | 2021-12-20 | 公開日 | 2022-06-29 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | 主引用文献 | Trimer-to-Monomer Disruption Mechanism for a Potent, Protease-Resistant Antagonist of Tumor Necrosis Factor-alpha Signaling. J.Am.Chem.Soc., 144, 2022
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7UZP
| parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing three beta-amino acids | 分子名称: | 1,2-ETHANEDIOL, PTHrP[1-36] 24,28,31 XCP, Parathyroid hormone/parathyroid hormone-related peptide receptor, ... | 著者 | Yu, Z, Bruchs, A.T, Bingman, C.A, Gellman, S.H. | 登録日 | 2022-05-09 | 公開日 | 2022-10-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo. Proc.Natl.Acad.Sci.USA, 119, 2022
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7UZO
| Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing one beta-amino acid | 分子名称: | Parathyroid hormone/parathyroid hormone-related peptide receptor, Peptide from Parathyroid hormone-related protein, ZINC ION | 著者 | Yu, Z, Bruchs, A.T, Bingman, C.A, Gellman, S.H. | 登録日 | 2022-05-09 | 公開日 | 2022-10-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo. Proc.Natl.Acad.Sci.USA, 119, 2022
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5AGX
| Bcl-2 alpha beta-1 LINEAR complex | 分子名称: | APOPTOSIS REGULATOR BCL-2, BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11 | 著者 | Smith, B.J, F Lee, E, Checco, J.W, Gellman, S.H, Fairlie, W.D. | 登録日 | 2015-02-04 | 公開日 | 2015-09-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Alpha Beta Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity on Living Cells J.Am.Chem.Soc., 137, 2015
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5AGW
| Bcl-2 alpha beta-1 complex | 分子名称: | APOPTOSIS REGULATOR BCL-2, BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11 | 著者 | Smith, B.J, F Lee, E, Checco, J.W, Gellman, S.H, Fairlie, W.D. | 登録日 | 2015-02-04 | 公開日 | 2015-09-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.695 Å) | 主引用文献 | Alpha Beta Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity on Living Cells J.Am.Chem.Soc., 137, 2015
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4RWB
| Racemic influenza M2-TM crystallized from monoolein lipidic cubic phase | 分子名称: | Matrix protein 2, [(Z)-octadec-9-enyl] (2R)-2,3-bis(oxidanyl)propanoate | 著者 | Mortenson, D.E, Steinkruger, J.D, Kreitler, D.F, Gellman, S.H, Forest, K.T. | 登録日 | 2014-12-02 | 公開日 | 2015-10-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | High-resolution structures of a heterochiral coiled coil. Proc.Natl.Acad.Sci.USA, 112, 2015
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4RWC
| Racemic M2-TM crystallized from racemic detergent | 分子名称: | Matrix protein 2, octyl beta-D-glucopyranoside | 著者 | Mortenson, D.E, Steinkruger, J.D, Kreitler, D.F, Gellman, S.H, Forest, K.T. | 登録日 | 2014-12-02 | 公開日 | 2015-10-14 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | High-resolution structures of a heterochiral coiled coil. Proc.Natl.Acad.Sci.USA, 112, 2015
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6D3O
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1JY9
| MINIMIZED AVERAGE STRUCTURE OF DP-TT2 | 分子名称: | DP-TT2 | 著者 | Stanger, H.E, Syud, F.A, Espinosa, J.F, Giriat, I, Muir, T, Gellman, S.H. | 登録日 | 2001-09-11 | 公開日 | 2001-09-19 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Length-dependent stability and strand length limits in antiparallel beta -sheet secondary structure. Proc.Natl.Acad.Sci.USA, 98, 2001
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2YJ1
| Puma BH3 foldamer in complex with Bcl-xL | 分子名称: | ALPHA-BETA-PUMA BH3 FOLDAMER, BCL-2-LIKE PROTEIN 1 | 著者 | Lee, E.F, Smith, B.J, Horne, W.S, Mayer, K.N, Evangelista, M, Colman, P.M, Gellman, S.H, Fairlie, W.D. | 登録日 | 2011-05-18 | 公開日 | 2011-10-12 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Structural Basis of Bcl-Xl Recognition by a Bh3-Mimetic Alpha-Beta-Peptide Generated Via Sequence-Based Design Chembiochem, 12, 2011
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4MGP
| Structure of racemic Ala-(8,13,18) Magainin 2 | 分子名称: | Magainin 2 Derivative | 著者 | Hayouka, Z, Mortenson, D.E, Kreitler, D.F, Weisblum, B, Gellman, S.H, Forest, K.T. | 登録日 | 2013-08-28 | 公開日 | 2013-10-16 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Evidence for Phenylalanine Zipper-Mediated Dimerization in the X-ray Crystal Structure of a Magainin 2 Analogue. J.Am.Chem.Soc., 135, 2013
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3C3H
| alpha/beta-Peptide helix bundles: A GCN4-pLI analogue with an (alpha-alpha-beta) backbone and cyclic beta residues | 分子名称: | alpha/beta-peptide based on the GCN4-pLI side chain sequence, with an (alpha-alpha-beta) backbone and cyclic beta-residues at positions 1, 4, ... | 著者 | Horne, W.S, Price, J.L, Gellman, S.H. | 登録日 | 2008-01-28 | 公開日 | 2008-06-17 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly. Proc.Natl.Acad.Sci.Usa, 105, 2008
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4A1U
| Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL | 分子名称: | ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1, CHLORIDE ION, ... | 著者 | Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D. | 登録日 | 2011-09-20 | 公開日 | 2011-12-28 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain. J.Am.Chem.Soc., 134, 2012
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