7S1M
 
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4GWT
 | | Structure of racemic Pin1 WW domain cocrystallized with DL-malic acid | | 分子名称: | (2S)-2-hydroxybutanedioic acid, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | | 著者 | Mortenson, D.E, Yun, H.G, Gellman, S.H, Forest, K.T. | | 登録日 | 2012-09-03 | | 公開日 | 2013-10-16 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Evidence for small-molecule-mediated loop stabilization in the structure of the isolated Pin1 WW domain.
Acta Crystallogr.,Sect.D, 69, 2013
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8D52
 | | Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing (2-naphthyl)-beta-3-homoalanine | | 分子名称: | 1,2-ETHANEDIOL, PTHrP[1-36], Parathyroid hormone/parathyroid hormone-related peptide receptor, ... | | 著者 | Yu, Z, Kreitler, D.F, Gellman, S.H. | | 登録日 | 2022-06-03 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Harnessing Aromatic-Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8D51
 | | Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing beta-3-homotryptophan | | 分子名称: | 1,2-ETHANEDIOL, PTHrP[1-36], Parathyroid hormone/parathyroid hormone-related peptide receptor, ... | | 著者 | Yu, Z, Kreitler, D.F, Gellman, S.H. | | 登録日 | 2022-06-03 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Harnessing Aromatic-Histidine Interactions through Synergistic Backbone Extension and Side Chain Modification.
Angew.Chem.Int.Ed.Engl., 62, 2023
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5VTJ
 | | Structure of Pin1 WW Domain Sequence 1 Substituted with [S,S]ACPC | | 分子名称: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, SULFATE ION | | 著者 | Mortenson, D.E, Kreitler, D.F, Thomas, N.C, Gellman, S.H, Forest, K.T. | | 登録日 | 2017-05-17 | | 公開日 | 2018-02-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Evaluation of beta-Amino Acid Replacements in Protein Loops: Effects on Conformational Stability and Structure.
Chembiochem, 19, 2018
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5VTI
 | | Structure of Pin1 WW Domain Sequence 3 with [R,R]-ACPC Loop Substitution | | 分子名称: | CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | | 著者 | Mortenson, D.E, Kreitler, D.F, Thomas, N.C, Gellman, S.H, Forest, K.T. | | 登録日 | 2017-05-17 | | 公開日 | 2018-02-21 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Evaluation of beta-Amino Acid Replacements in Protein Loops: Effects on Conformational Stability and Structure.
Chembiochem, 19, 2018
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4WPB
 | | Vascular endothelial growth factor in complex with alpha/beta-VEGF-1 | | 分子名称: | Vascular endothelial growth factor A, alpha/beta-VEGF-1 | | 著者 | Kreitler, D.F, Checco, J.W, Gellman, S.H, Forest, K.T. | | 登録日 | 2014-10-17 | | 公開日 | 2015-04-15 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | | 主引用文献 | Targeting diverse protein-protein interaction interfaces with alpha / beta-peptides derived from the Z-domain scaffold.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4A1U
 | | Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL | | 分子名称: | ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1, CHLORIDE ION, ... | | 著者 | Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D. | | 登録日 | 2011-09-20 | | 公開日 | 2011-12-28 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain.
J.Am.Chem.Soc., 134, 2012
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4A1W
 | | Crystal structure of alpha-beta foldamer 4c in complex with Bcl-xL | | 分子名称: | ALPHA-BETA-FOLDAMER 2C, BCL-2-LIKE PROTEIN 1 | | 著者 | Boersma, M.D, Haase, H.S, Kaufman, K.J, Horne, W.S, Lee, E.F, Clarke, O.B, Smith, B.J, Colman, P.M, Gellman, S.H, Fairlie, W.D. | | 登録日 | 2011-09-20 | | 公開日 | 2011-12-28 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.497 Å) | | 主引用文献 | Evaluation of Diverse Alpha/Beta-Backbone Patterns for Functional Alpha-Helix Mimicry: Analogues of the Bim Bh3 Domain.
J.Am.Chem.Soc., 134, 2012
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5I1N
 | | Villin headpiece subdomain with a Gln26 to beta-3-homoglutamine substitution | | 分子名称: | D-Villin headpiece subdomain, Villin-1 | | 著者 | Kreitler, D.F, Mortenson, D.E, Gellman, S.H, Forest, K.T. | | 登録日 | 2016-02-05 | | 公開日 | 2016-05-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Effects of Single alpha-to-beta Residue Replacements on Structure and Stability in a Small Protein: Insights from Quasiracemic Crystallization.
J.Am.Chem.Soc., 138, 2016
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2JM0
 | | Solution structure of chicken villin headpiece subdomain containing a fluorinated side chain in the core | | 分子名称: | Villin-1 | | 著者 | Cornilescu, C.C, Cornilescu, G, Hadley, E.B, Gellman, S.H, Markley, J.L. | | 登録日 | 2006-09-06 | | 公開日 | 2006-10-17 | | 最終更新日 | 2023-12-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of a small protein containing a fluorinated side chain in the core.
Protein Sci., 16, 2007
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5I1P
 | | Villin headpiece subdomain with a Lys30 to beta-3-homolysine substitution | | 分子名称: | D-Villin headpiece subdomain, ETHANOL, Villin-1 | | 著者 | Kreitler, D.F, Mortenson, D.E, Gellman, S.H, Forest, K.T. | | 登録日 | 2016-02-05 | | 公開日 | 2016-05-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Effects of Single alpha-to-beta Residue Replacements on Structure and Stability in a Small Protein: Insights from Quasiracemic Crystallization.
J.Am.Chem.Soc., 138, 2016
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5I1O
 | | Villin headpiece subdomain with a Gln26 to ACPC substitution | | 分子名称: | D-Villin headpiece subdomain, Villin-1 | | 著者 | Kreitler, D.F, Mortenson, D.E, Gellman, S.H, Forest, K.T. | | 登録日 | 2016-02-05 | | 公開日 | 2016-05-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.348 Å) | | 主引用文献 | Effects of Single alpha-to-beta Residue Replacements on Structure and Stability in a Small Protein: Insights from Quasiracemic Crystallization.
J.Am.Chem.Soc., 138, 2016
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5I1S
 | | Villin headpiece subdomain with a Lys30 to APC substitution | | 分子名称: | D-Villin headpiece subdomain, Villin-1 | | 著者 | Kreitler, D.F, Mortenson, D.E, Gellman, S.H, Forest, K.T. | | 登録日 | 2016-02-05 | | 公開日 | 2016-05-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | | 主引用文献 | Effects of Single alpha-to-beta Residue Replacements on Structure and Stability in a Small Protein: Insights from Quasiracemic Crystallization.
J.Am.Chem.Soc., 138, 2016
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7TA6
 | | Trimer-to-Monomer Disruption of Tumor Necrosis Factor-alpha (TNF-alpha) by unnatural alpha/beta-peptide-1 | | 分子名称: | 1,2-ETHANEDIOL, AMINO GROUP, Alpha/Beta-peptide-1, ... | | 著者 | Niu, J, Bingman, C.A, Gellman, S.H. | | 登録日 | 2021-12-20 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Trimer-to-Monomer Disruption Mechanism for a Potent, Protease-Resistant Antagonist of Tumor Necrosis Factor-alpha Signaling.
J.Am.Chem.Soc., 144, 2022
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7TA3
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7UZO
 | | Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing one beta-amino acid | | 分子名称: | Parathyroid hormone/parathyroid hormone-related peptide receptor, Peptide from Parathyroid hormone-related protein, ZINC ION | | 著者 | Yu, Z, Bruchs, A.T, Bingman, C.A, Gellman, S.H. | | 登録日 | 2022-05-09 | | 公開日 | 2022-10-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7UZP
 | | parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing three beta-amino acids | | 分子名称: | 1,2-ETHANEDIOL, PTHrP[1-36] 24,28,31 XCP, Parathyroid hormone/parathyroid hormone-related peptide receptor, ... | | 著者 | Yu, Z, Bruchs, A.T, Bingman, C.A, Gellman, S.H. | | 登録日 | 2022-05-09 | | 公開日 | 2022-10-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo.
Proc.Natl.Acad.Sci.USA, 119, 2022
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6O4M
 | | Racemic melittin | | 分子名称: | D-Melittin, Melittin, SULFATE ION | | 著者 | Kurgan, K.W, Bingman, C.A, Gellman, S.H, Forest, K.T. | | 登録日 | 2019-02-28 | | 公開日 | 2019-05-22 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | | 主引用文献 | Retention of Native Quaternary Structure in Racemic Melittin Crystals.
J.Am.Chem.Soc., 141, 2019
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6PRL
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6PYQ
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6PZ6
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6V3V
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2YJ1
 | | Puma BH3 foldamer in complex with Bcl-xL | | 分子名称: | ALPHA-BETA-PUMA BH3 FOLDAMER, BCL-2-LIKE PROTEIN 1 | | 著者 | Lee, E.F, Smith, B.J, Horne, W.S, Mayer, K.N, Evangelista, M, Colman, P.M, Gellman, S.H, Fairlie, W.D. | | 登録日 | 2011-05-18 | | 公開日 | 2011-10-12 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Structural Basis of Bcl-Xl Recognition by a Bh3-Mimetic Alpha-Beta-Peptide Generated Via Sequence-Based Design
Chembiochem, 12, 2011
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6VAS
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